HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	9592050, 18467332
Identification Methods	affinity chromatography technology, unspecified method, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1290
+	Hs
		580935 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		496239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		497050 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB4_HUMAN (714-1286): 6.01e-96: 336: 21.31
+	Hs
		497635 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB1_HUMAN (713-1287): 4.04e-91: 323: 20.97
+	Hs
		496595 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCD1_HUMAN (734-1213): 1.5e-93: 320: 23.73
+	Dm
		632600 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PIP1_DROME (941-1246): 1.33e-79: 289: 31.63