HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26269332
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 551
+	Hs
		496245 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCA_HUMAN (75-547): 2.61e-127: 389: 16.26
+	Hs
		408538 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCB_HUMAN (75-548): 9.31e-125: 382: 15.58
+	Hs
		397126 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCG_HUMAN (75-548): 1.94e-122: 377: 15.12
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (118-545): 1.39e-124: 375: 18.04
+	Hs
		496879 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCE_HUMAN (103-548): 8.91e-120: 371: 19.01
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (118-544): 3.32e-122: 369: 20.09
+	Hs
		277594 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PAK3_HUMAN (24-549): 3.26e-120: 367: 14.11
+	Hs
		497299 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DCLK2_HUMAN (71-548): 2.8e-110: 347: 20.36
+	Rn
		581978 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KPCB_RAT (75-548): 1.79e-124: 382: 15.77
+	Rn
		94201 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KPCB_RAT (75-548): 1.79e-124: 382: 15.77
+	Mm
		497997 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KPCG_MOUSE (75-548): 1.84e-122: 377: 14.94
+	Mm
		498062 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DCLK2_MOUSE (71-548): 7.59e-111: 349: 20.56
+	Hs
		554297 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		KPCD_HUMAN (43-548): 7.52e-133: 403: 15.77
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (118-544): 3.32e-122: 369: 20.09
+	Hs
		653939 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41
+	Hs
		851493 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41