HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34349018, 21145461
Identification Methods	cross-linking study, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 759
+	Hs
		713966 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		504043 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		713967 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		504044 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		502077 BIP_HUMAN (19-654): 0: 914: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		713965 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		504042 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		502075 BIP_HUMAN (19-654): 0: 914: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		713963 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		504040 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		564073 HSP76_HUMAN (25-635): 0: 915: 62.54		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		502073 BIP_HUMAN (19-654): 0: 914: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		713964 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		504041 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		502074 BIP_HUMAN (19-654): 0: 914: 100.00		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		714040 HS71L_HUMAN (24-647): 0: 922: 63.16		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Hs
		504518 HSP7C_HUMAN (26-637): 0: 916: 66.02		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Hs
		502399 BIP_HUMAN (19-654): 0: 914: 100.00		CUL5_HUMAN (59-759): 0: 589: 24.94