Protein: KDM4A
Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)

Gene: KDM4A
Organism: Homo sapiens
Interactions: 87
UniProt ID: O75164

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001650 - fibrillar center
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005721 - pericentric heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273385

KDM4B
Lysine-specific demethylase 4B

2

15

High-throughput

0.789

High

273420

H31
Histone H3.1

4

20

Small-scale

0.700

High

273456

KDM5B
Lysine-specific demethylase 5B

1

12

High-throughput

0.691

High

273417

H4
Histone H4

3

6

Small-scale

0.671

High

273430

STK11
Serine/threonine-protein kinase STK11

3

1

High-throughput

0.662

High

273445

ZN414
Zinc finger protein 414

2

2

High-throughput

0.628

High

273382

NCOR1
Nuclear receptor corepressor 1

2

6

Small-scale

0.624

High

273381

KDM4A
Lysine-specific demethylase 4A

1

15

Small-scale

0.618

High

273439

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

6

Small-scale

0.618

High

273453

KDM4C
Lysine-specific demethylase 4C

1

15

Small-scale

0.618

High

273436

FBX22
F-box only protein 22

2

3

Small-scale

0.584

High

104009

F5GX28
Lysine-specific demethylase 4B

1

16

High-throughput

0.575

High

142192

CCL22
C-C motif chemokine 22

2

1

High-throughput

0.574

High

273388

P53
Cellular tumor antigen p53

2

5

Small-scale

0.571

High

273422

H33
Histone H3.3

2

20

Small-scale

0.571

High

273429

CUL1
Cullin-1

2

3

Small-scale

0.571

High

273432

H31T
Histone H3.1t

1

20

Small-scale

0.568

High

273396

ERG
Transcriptional regulator ERG

1

4

Small-scale

0.561

High

273390

RB
Retinoblastoma-associated protein

1

4

Small-scale

0.552

High

273442

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.541

High

273384

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.536

High

273387

CYTA
Cystatin-A

1

1

High-throughput

0.536

High

273392

S10A9
Protein S100-A9

1

2

High-throughput

0.536

High

273394

H2AZ
Histone H2A.Z

1

4

High-throughput

0.536

High

273416

SMD2
Small nuclear ribonucleoprotein Sm D2

1

1

High-throughput

0.536

High

273418

TRA2B
Transformer-2 protein homolog beta

1

4

High-throughput

0.536

High

273419

TBA1B
Tubulin alpha-1B chain

1

3

High-throughput

0.536

High

273425

SRSF1
Serine/arginine-rich splicing factor 1

1

1

High-throughput

0.536

High

273426

STK4
Serine/threonine-protein kinase 4

1

2

High-throughput

0.536

High

273427

CAF1B
Chromatin assembly factor 1 subunit B

1

7

High-throughput

0.536

High

273437

WDR48
WD repeat-containing protein 48

1

8

High-throughput

0.536

High

273459

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.536

High

169030

ML12B
Myosin regulatory light chain 12B

1

0

High-throughput

0.513

High

273386

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

273389

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

273398

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

273401

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

0

High-throughput

0.513

High

273440

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.513

High

273441

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

1

0

High-throughput

0.513

High

273451

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.513

High

273383

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

Small-scale

0.501

High

273438

POC1B
POC1 centriolar protein homolog B

1

5

High-throughput

0.489

High

273448

CCL19
C-C motif chemokine 19

1

1

High-throughput

0.489

High

273399

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.484

High

273405

MCM7
DNA replication licensing factor MCM7

1

7

Small-scale

0.484

High

273435

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.480

High

188128

HDAC3
Histone deacetylase 3

1

13

Small-scale

0.479

High

240265

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

273395

ANDR
Androgen receptor

1

19

Small-scale

0.479

High

273410

WASP
Actin nucleation-promoting factor WAS

1

1

Small-scale

0.479

High

273413

ZN131
Zinc finger protein 131

1

4

High-throughput

0.479

High

273414

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

Small-scale

0.479

High

273428

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.479

High

273433

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

273449

CDC6
Cell division control protein 6 homolog

1

5

Small-scale

0.479

High

273450

ASCL2
Achaete-scute homolog 2

1

4

Small-scale

0.479

High

273457

FBXL4
F-box/LRR-repeat protein 4

1

2

Small-scale

0.479

High

273415

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.458

High

273455

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

273458

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.457

High

273393

DPOLA
DNA polymerase alpha catalytic subunit

1

3

Small-scale

0.445

High

273400

DPOD1
DNA polymerase delta catalytic subunit

1

3

Small-scale

0.445

High

273403

MCM4
DNA replication licensing factor MCM4

1

7

Small-scale

0.445

High

273404

MCM5
DNA replication licensing factor MCM5

1

8

Small-scale

0.445

High

273406

RFC4
Replication factor C subunit 4

1

6

Small-scale

0.445

High

273407

RFC2
Replication factor C subunit 2

1

6

Small-scale

0.445

High

273409

RFC5
Replication factor C subunit 5

1

6

Small-scale

0.445

High

273412

MCM2
DNA replication licensing factor MCM2

1

7

Small-scale

0.445

High

273424

DPOE1
DNA polymerase epsilon catalytic subunit A

1

3

Small-scale

0.445

High

273431

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.445

High

273434

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.445

High

273443

RENT1
Regulator of nonsense transcripts 1

1

1

Small-scale

0.445

High

273444

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

Small-scale

0.445

High

273447

WRIP1
ATPase WRNIP1

1

9

Small-scale

0.445

High

273460

TRRAP
Transformation/transcription domain-associated protein

1

1

Small-scale

0.445

High

273411

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

2

Small-scale

0.437

High

273452

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

273391

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.426

High

273402

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

Small-scale

0.426

High

273423

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.426

High

273454

CYBP
Calcyclin-binding protein

1

0

Small-scale

0.426

High

58775

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

273421

DCD
Dermcidin

1

0

High-throughput

0.279

Low

273397

RHOQ
Rho-related GTP-binding protein RhoQ

1

0

Small-scale

0.249

Low

273408

GPV
Platelet glycoprotein V

1

0

Small-scale

0.249

Low

273446

PANX2
Pannexin-2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025