HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	32687490, 24189400, 31980649, 19380743, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 583
+	Hs
		666014 HS71L_HUMAN (2-646): 0: 966: 82.48		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		564012 HSP76_HUMAN (6-646): 0: 955: 77.54		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		503732 HSP7C_HUMAN (1-646): 0: 967: 100.00		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Hs
		442767 HSP7C_HUMAN (1-646): 0: 967: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		503720 HSP7C_HUMAN (1-646): 0: 967: 100.00		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		442775 HSP76_HUMAN (6-646): 0: 955: 77.54		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		503489 HSP7C_HUMAN (1-646): 0: 967: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Rn
		926185 HSP7C_RAT (1-646): 0: 967: 99.85		GRB7_RAT (371-563): 1.44e-37: 148: 22.06
+	Hs
		504078 HSP7C_HUMAN (1-646): 0: 967: 100.00		GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57
+	Hs
		129181 HSP7C_HUMAN (1-646): 0: 967: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129217 HS71L_HUMAN (2-646): 0: 966: 82.48		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129192 HSP76_HUMAN (6-646): 0: 955: 77.54		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		504662 HSP7C_HUMAN (1-646): 0: 967: 100.00		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		503853 HSP7C_HUMAN (1-646): 0: 967: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		713938 HS71L_HUMAN (2-646): 0: 966: 82.48		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48