HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	20932831, 10713090
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 540
+	Hs
		507829 FGFR1_HUMAN (1-822): 0: 861: 100.00		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		508074 FGFR1_HUMAN (1-822): 0: 861: 100.00		RAPH1_HUMAN (101-438): 2.76e-82: 280: 30.88
+	Hs
		507964 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITK_HUMAN (237-535): 7.09e-58: 205: 17.14
+	Hs
		507843 FGFR1_HUMAN (1-822): 0: 861: 100.00		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		433229 FGFR1_HUMAN (1-822): 0: 861: 100.00		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Rn
		499160 FGFR1_RAT (1-822): 0: 849: 97.69		PLCG1_RAT (238-540): 8.25e-43: 166: 17.98
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		580923 FGFR2_HUMAN (1-821): 0: 803: 71.21		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		433573 FGFR2_HUMAN (1-821): 0: 803: 71.21		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		507959 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		412008 FGFR2_HUMAN (1-821): 0: 803: 71.21		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Hs
		507870 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		601501 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		601463 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		580927 FGFR3_HUMAN (6-821): 0: 730: 61.22		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		601466 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		609260 FGFR3_HUMAN (6-821): 0: 730: 61.22		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		609182 FGFR3_HUMAN (6-821): 0: 730: 61.22		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60