Protein: PIGS
GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein)

Gene: PIGS
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q96S52

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0016255 - attachment of GPI anchor to protein
GO:0042765 - GPI-anchor transamidase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1281728

PIGT
GPI transamidase component PIG-T

5

2

Small-scale

0.718

High

1268715

GPI8
GPI-anchor transamidase

4

1

Small-scale

0.683

High

200057

GPAA1
Glycosylphosphatidylinositol anchor attachment 1 protein

4

1

Small-scale

0.678

High

1301700

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

High-throughput

0.611

High

1301702

TSP50
Probable threonine protease PRSS50

3

1

High-throughput

0.609

High

1301690

PIGU
Phosphatidylinositol glycan anchor biosynthesis class U protein

2

1

Small-scale

0.601

High

1189406

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.578

High

889872

KR109
Keratin-associated protein 10-9

2

4

High-throughput

0.553

High

1216374

KRA13
Keratin-associated protein 1-3

2

6

High-throughput

0.553

High

1301686

KRA92
Keratin-associated protein 9-2

2

6

High-throughput

0.553

High

310767

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.536

High

580384

TSN8
Tetraspanin-8

1

2

High-throughput

0.536

High

654688

CALX
Calnexin

1

1

High-throughput

0.536

High

1301694

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

1

High-throughput

0.536

High

1301705

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

1301695

FBX6
F-box only protein 6

2

1

High-throughput

0.533

High

889634

KR108
Keratin-associated protein 10-8

1

6

High-throughput

0.523

High

168574

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.513

High

243565

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.513

High

276387

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.513

High

321349

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

439851

NEP
Neprilysin

1

0

High-throughput

0.513

High

452165

CD7
T-cell antigen CD7

1

0

High-throughput

0.513

High

452266

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

525605

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.513

High

728647

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

833306

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

1016662

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1185626

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1235957

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

1253871

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1261930

CD003
Uncharacterized protein C4orf3

1

0

High-throughput

0.513

High

1266828

TM131
Transmembrane protein 131

1

0

High-throughput

0.513

High

1281680

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1283248

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1301688

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1301689

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1301692

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

326188

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

905552

TSN5
Tetraspanin-5

1

2

High-throughput

0.489

High

997446

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.489

High

1230164

CNTRB
Centrobin

1

1

High-throughput

0.489

High

1301699

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.489

High

1301703

FBX2
F-box only protein 2

1

1

High-throughput

0.489

High

545572

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.479

High

894339

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

900825

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

1168641

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1204816

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

1240732

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1255667

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1296639

CALR3
Calreticulin-3

1

1

High-throughput

0.479

High

484687

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

1301687

KRA24
Keratin-associated protein 2-4

1

6

High-throughput

0.470

High

48468

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

725857

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

815808

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

890362

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1066130

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.458

High

1087595

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1165295

KIRR2
Kin of IRRE-like protein 2

1

0

High-throughput

0.458

High

1165877

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1284021

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1286079

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1301684

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

473334

KRA23
Keratin-associated protein 2-3

1

6

High-throughput

0.439

High

888964

KR103
Keratin-associated protein 10-3

1

6

High-throughput

0.439

High

120596

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

553494

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

1026516

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1156683

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1222078

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1292836

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1301691

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1301693

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.437

High

354981

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

0

High-throughput

0.426

High

529604

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1241581

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

99663

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

315904

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.328

High

310340

LYPD3
Ly6/PLAUR domain-containing protein 3

2

0

High-throughput

0.318

High

1076513

TRIP6
Thyroid receptor-interacting protein 6

2

0

High-throughput

0.316

High

1109088

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1149304

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

206517

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

245511

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

268832

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.279

Low

278863

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.279

Low

380190

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.279

Low

474767

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

528389

MYH6
Myosin-6

1

0

High-throughput

0.279

Low

540333

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

678576

MK04
Mitogen-activated protein kinase 4

1

0

High-throughput

0.279

Low

783716

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.279

Low

1016544

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.279

Low

1073716

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.279

Low

1103916

CO032
Uncharacterized protein C15orf32

1

0

High-throughput

0.279

Low

1108501

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.279

Low

1160171

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.279

Low

1218922

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1222039

MILK2
MICAL-like protein 2

1

0

High-throughput

0.279

Low

1268635

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

1274314

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.279

Low

1294727

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

0

High-throughput

0.279

Low

1301685

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.279

Low

1301696

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.279

Low

1301704

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

1109351

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

602

NBPFJ
Neuroblastoma breakpoint family member 19

1

0

High-throughput

0.251

Low

1191242

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

205863

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

228435

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

474528

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.249

Low

531955

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

637284

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

652021

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

658132

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.249

Low

721221

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

845188

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

941337

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1053636

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1086742

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1087690

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

1148741

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1165574

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

1171339

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1220965

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1269420

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1301697

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1301698

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1301701

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

209278

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024