Protein: DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]

Gene: DNA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 33
UniProt ID: P38859

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000723 - telomere maintenance
GO:0000706 - meiotic DNA double-strand break processing
GO:0000729 - DNA double-strand break processing
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607271

RFA1
Replication factor A protein 1

11

3

Small-scale

0.757

High

644754

RFA2
Replication factor A protein 2

3

3

Small-scale

0.656

High

756335

LCD1
DNA damage checkpoint protein LCD1

3

0

High-throughput

0.634

High

339622

CDK1
Cyclin-dependent kinase 1

2

3

Small-scale

0.629

High

715640

SGS1
ATP-dependent helicase SGS1

2

14

Small-scale

0.625

High

645745

FEN1
Flap endonuclease 1

2

7

Small-scale

0.621

High

511268

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.601

High

755890

YHS2
MIP18 family protein YHR122W

2

2

High-throughput

0.596

High

756334

CTF4
DNA polymerase alpha-binding protein

1

8

Small-scale

0.594

High

698593

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.581

High

644800

RFA3
Replication factor A protein 3

2

0

High-throughput

0.576

High

493936

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

694676

HSP7F
Heat shock protein homolog SSE1

2

13

High-throughput

0.552

High

525776

TOP3
DNA topoisomerase 3

1

3

Small-scale

0.515

High

618832

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

2

Small-scale

0.501

High

756336

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.501

High

686914

PROB
Glutamate 5-kinase

1

0

High-throughput

0.493

High

550544

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

679863

FUN30
ATP-dependent helicase FUN30

1

2

Small-scale

0.479

High

744133

ATR
Serine/threonine-protein kinase MEC1

1

8

High-throughput

0.479

High

756332

MET18
DNA repair/transcription protein MET18/MMS19

1

1

High-throughput

0.479

High

704666

PRP8
Pre-mRNA-splicing factor 8

1

0

Small-scale

0.460

High

756333

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.460

High

756337

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

Small-scale

0.460

High

366271

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

368045

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

478178

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

543704

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

633214

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

695962

HSP79
Heat shock protein homolog SSE2

1

13

High-throughput

0.445

High

705160

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

756331

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

689787

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024