Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 0.60 0.678

The method score is based on:

Property Details
Experiments 28415827, 35271311, 21679440
Identification Methods affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 4 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 765
Hs

1 732
+ Hs
+ Hs

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Last updated: 15 Jul 2024