HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 1054
+	Hs
		229291 TOP1_HUMAN (1-765): 0: 932: 100.00		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		508484 TOP1_HUMAN (1-765): 0: 932: 100.00		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		508529 TOP1_HUMAN (1-765): 0: 932: 100.00		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1059780 TOP1M_HUMAN (183-765): 0: 871: 68.72		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		508402 TOP1_HUMAN (1-765): 0: 932: 100.00		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Zm
		26286 A0A1D6PW39_MAIZE (46-765): 0: 798: 39.30		A0A1D6J209_MAIZE (17-790): 0: 690: 33.50
+	Sc
		388099 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		ISW1_YEAST (70-1049): 0: 805: 47.63
+	Dm
		332845 Q9VGW4_DROME (2-215): 1.22e-09: 64.4: 15.04		CHDM_DROME (27-954): 0: 737: 29.21