Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A
Interactor 2: TOP2B (Q02880)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.63 | 1.00 | 0.799 |
The method score is based on:
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DNA_gyraseB~DNA_gyraseB, DNA_gyraseB~DNA_topoisoIV, DNA_gyraseB~HATPase_c, DNA_gyraseB~Toprim, DNA_topoisoIV~DNA_topoisoIV, DNA_topoisoIV~Toprim, DNA_topoisoIV~TOPRIM_C, HATPase_c~HATPase_c, Toprim~Toprim, TOPRIM_C~Toprim |
| Common GO terms | GO:0000712 - resolution of meiotic recombination intermediates GO:0000819 - sister chromatid segregation GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity and 7 others more... |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
