HitPredict

Interactor 1: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	21715324, 28190767, 29676259, 31362587, 23637164
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 734 Mm			1 442
+	Hs
		507932 UBC_HUMAN (77-724): 0: 798: 97.22		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Mm
		509194 UBC_MOUSE (1-734): 0: 922: 100.00		MIB2_MOUSE (106-206): 3.86e-13: 73.6: 28.16
+	Mm
		509071 UBC_MOUSE (1-734): 0: 922: 100.00		HERC2_MOUSE (120-197): 1.06e-11: 69.4: 32.50
+	Rn
		93331 UBC_RAT (1-724): 0: 907: 97.51		D4ACN3_RAT (120-197): 1.09e-11: 69.4: 32.50
+	Hs
		508238 UBC_HUMAN (77-724): 0: 798: 97.22		MIB1_HUMAN (105-228): 1.66e-27: 117: 27.69
+	Hs
		508397 UBC_HUMAN (77-724): 0: 798: 97.22		MIB2_HUMAN (106-219): 7.5e-14: 75.9: 27.59
+	Hs
		342725 UBC_HUMAN (77-724): 0: 798: 97.22		HERC2_HUMAN (120-197): 1.36e-11: 69: 32.50
+	Hs
		987012 RS27A_HUMAN (609-684): 3.68e-42: 152: 100.00		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Xl
		1232880 Q7SY79_XENLA (153-724): 0: 714: 96.85		MIB1_XENLA (105-228): 2.17e-27: 117: 27.69
+	Hs
		181991 UBD_HUMAN (155-304): 2.53e-28: 113: 32.05		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		507189 UBB_HUMAN (1-77): 1.49e-27: 113: 98.70		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Dr
		47837 F1QHN6_DANRE (229-724): 0: 609: 96.37		A0AR23_DANRE (106-219): 6.98e-13: 72.9: 25.00
+	Dr
		47846 Q6IS68_DANRE (374-724): 5.58e-140: 426: 93.16		A0AR23_DANRE (106-219): 6.98e-13: 72.9: 25.00
+	Dr
		47847 Q7SXA3_DANRE (609-684): 1.84e-42: 152: 100.00		A0AR23_DANRE (106-219): 6.98e-13: 72.9: 25.00