HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: DDB2 (Q92466)
DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)
Gene: DDB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0032991 - protein-containing complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 427
+	Hs
		509081 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		FBXW7_HUMAN (5-311): 1.3e-61: 213: 12.14
+	Hs
		508975 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		ERCC8_HUMAN (114-324): 1.48e-59: 201: 23.21
+	Hs
		973372 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		DDB2_HUMAN (1-427): 1.81e-95: 294: 100.00
+	Hs
		508856 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		LIS1_HUMAN (5-231): 5.78e-48: 170: 12.20
+	Hs
		509143 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		NLE1_HUMAN (279-427): 4.77e-30: 123: 16.77
+	Hs
		973378 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		FBXW7_HUMAN (5-311): 1.3e-61: 213: 12.14
+	Hs
		509088 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		SNR40_HUMAN (272-427): 1.08e-24: 106: 12.58
+	Hs
		973406 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		NLE1_HUMAN (279-427): 4.77e-30: 123: 16.77
+	Hs
		973382 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		SNR40_HUMAN (272-427): 1.08e-24: 106: 12.58
+	Sc
		420196 TOP2_YEAST (24-1404): 0: 1262: 41.63		CMR1_YEAST (98-427): 4.9e-26: 112: 17.49