HitPredict

Interactor 1: A1Z6I7 (A1Z6I7)
Bub1-related kinase
Gene: BubR1

Interactor 2: Q24044 (Q24044)
FI02843p (Fizzy) (LD44795p)
Gene: fzy

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	23685359, 26553926, 31913420, 20421417
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~Mad3_BUB1_I, Mad3_BUB1_I~WD40
Common GO terms	GO:0000776 - kinetochore
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1460 Dm			1 526
+	Mm
		593490 KPCA_MOUSE (956-1458): 1.81e-121: 396: 12.21		FBXW7_MOUSE (36-522): 1.11e-89: 291: 17.44
+	Hs
		681967 AKT1_HUMAN (1063-1458): 2.06e-121: 390: 13.55		FBXW7_HUMAN (36-522): 3.31e-89: 290: 17.44
+	Ce
		998495 BUB1_CAEEL (919-1456): 3.29e-87: 309: 22.34		FZY1_CAEEL (45-504): 2.36e-121: 367: 27.81
+	Hs
		211008 BUB1_HUMAN (41-287): 1.34e-71: 263: 30.77		CDC20_HUMAN (1-526): 5.72e-116: 353: 49.34
+	Hs
		236918 BUB1B_HUMAN (674-1457): 2.48e-70: 259: 13.81		CDC20_HUMAN (1-526): 5.72e-116: 353: 49.34
+	Hs
		903250 MYLK_HUMAN (601-1460): 1.03e-121: 422: 13.10		WDR5_HUMAN (105-412): 2.78e-55: 190: 15.89
+	Mm
		1337484 BUB1B_MOUSE (675-1459): 1.43e-68: 254: 14.05		CDC20_MOUSE (1-526): 4.34e-115: 351: 50.10
+	Hs
		324857 M4K4_HUMAN (1175-1450): 2.82e-51: 200: 26.42		FBXW7_HUMAN (36-522): 3.31e-89: 290: 17.44
+	Hs
		682069 AKT1_HUMAN (1063-1458): 2.06e-121: 390: 13.55		FZR1_HUMAN (340-511): 3.2e-19: 92.4: 18.29
+	At
		187359 BUBR1_ARATH (2-330): 4.1e-102: 333: 26.87		CDC22_ARATH (355-523): 2.45e-24: 107: 16.86
+	At
		187360 BUBR1_ARATH (2-330): 4.1e-102: 333: 26.87		CDC21_ARATH (355-523): 2.05e-24: 107: 16.86
+	Hs
		793038 TNIK_HUMAN (1175-1450): 8.57e-48: 189: 24.84		LIS1_HUMAN (241-523): 8.74e-75: 244: 15.13
+	Hs
		211075 BUB1_HUMAN (41-287): 1.34e-71: 263: 30.77		FZR1_HUMAN (340-511): 3.2e-19: 92.4: 18.29
+	Hs
		236994 BUB1B_HUMAN (674-1457): 2.48e-70: 259: 13.81		FZR1_HUMAN (340-511): 3.2e-19: 92.4: 18.29
+	Sc
		640849 BUB1_YEAST (28-419): 1.82e-60: 228: 15.87		CDC20_YEAST (37-385): 4.99e-12: 70.2: 16.14
+	At
		1322631 Q9FFG4_ARATH (26-195): 5.6e-50: 186: 24.71		CDC22_ARATH (355-523): 2.45e-24: 107: 16.86
+	At
		1322632 Q9FFG4_ARATH (26-195): 5.6e-50: 186: 24.71		CDC21_ARATH (355-523): 2.05e-24: 107: 16.86
+	Sc
		640852 MAD3_YEAST (2-275): 5.47e-59: 214: 24.21		CDC20_YEAST (37-385): 4.99e-12: 70.2: 16.14