HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PB1~Pkinase, Pkinase~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0007165 - signal transduction GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 448
+	Hs
		960163 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		682166 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86
+	Hs
		414773 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	At
		1114822 MPK16_ARATH (4-302): 1.74e-122: 363: 32.69		CDPK8_ARATH (115-446): 2.81e-125: 375: 18.95
+	Hs
		515349 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		681793 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	At
		1106294 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		CDPK3_ARATH (166-446): 3.62e-122: 367: 21.58
+	Hs
		515431 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		KCC1A_HUMAN (157-445): 7.74e-123: 363: 21.55
+	Hs
		960087 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		960088 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		STK3_HUMAN (138-421): 1.6e-106: 326: 32.53
+	At
		1106388 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		M2K2_ARATH (136-423): 3.46e-116: 346: 37.63
+	At
		1259060 MPK16_ARATH (4-302): 1.74e-122: 363: 32.69		M2K2_ARATH (136-423): 3.46e-116: 346: 37.63
+	Hs
		414899 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		STK3_HUMAN (138-421): 1.6e-106: 326: 32.53
+	At
		1106332 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		M2K1_ARATH (109-433): 1.72e-108: 326: 35.44
+	At
		1106354 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		M2K6_ARATH (140-429): 2.94e-104: 315: 37.92
+	Hs
		414789 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Sp
		489655 SPK1_SCHPO (3-303): 3.09e-123: 358: 32.58		BYR1_SCHPO (172-421): 4.34e-73: 234: 47.45
+	Hs
		515369 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		805394 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	At
		285305 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		M2K4_ARATH (162-421): 5.92e-49: 172: 37.69