Protein: STE20
Serine/threonine-protein kinase STE20 (EC 2.7.11.1)

Gene: STE20
Organism: Saccharomyces cerevisiae S288C
Interactions: 184
UniProt ID: Q03497

Gene Ontology (top 5):
GO:0000011 - vacuole inheritance
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000131 - incipient cellular bud site
GO:0000165 - MAPK cascade
GO:0000282 - cellular bud site selection

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618359

CDC42
Cell division control protein 42

21

20

Small-scale

0.988

High

632438

CG12
G1/S-specific cyclin CLN2

5

12

Small-scale

0.906

High

660340

STE11
Serine/threonine-protein kinase STE11

3

18

Small-scale

0.845

High

1042989

STE20
Serine/threonine-protein kinase STE20

3

17

Small-scale

0.835

High

924419

CBK1
Serine/threonine-protein kinase CBK1

2

18

Small-scale

0.793

High

792442

BOI1
BEM1-interacting protein 1

2

9

High-throughput

0.781

High

364716

CDK1
Cyclin-dependent kinase 1

2

10

Small-scale

0.768

High

711524

BEM1
Bud emergence protein 1

15

20

Small-scale

0.763

High

579972

HSC82
ATP-dependent molecular chaperone HSC82

2

20

High-throughput

0.754

High

1043015

NBP2
NAP1-binding protein 2

7

3

Small-scale

0.750

High

671062

SIS1
Protein SIS1

2

10

High-throughput

0.737

High

816047

BOI2
BEM1-interacting protein 2

1

9

High-throughput

0.656

High

646516

RAD53
Serine/threonine-protein kinase RAD53

1

18

Small-scale

0.647

High

656994

BUR1
Serine/threonine-protein kinase BUR1

1

16

Small-scale

0.647

High

667063

CG21
G2/mitotic-specific cyclin-1

1

6

High-throughput

0.647

High

692615

NSR1
Nuclear localization sequence-binding protein

1

6

High-throughput

0.647

High

745859

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

8

High-throughput

0.647

High

803206

RIM4
Meiotic activator RIM4

1

9

High-throughput

0.647

High

835525

AZF1
Transcription factor AZF1

1

4

High-throughput

0.647

High

851012

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.647

High

925346

CRZ1
Transcriptional regulator CRZ1

1

9

High-throughput

0.647

High

1027268

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

9

Small-scale

0.647

High

1043011

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

5

High-throughput

0.647

High

542985

CDC24
Cell division control protein 24

3

10

Small-scale

0.645

High

617415

GBB
Guanine nucleotide-binding protein subunit beta

2

11

Small-scale

0.634

High

763236

PP2C1
Protein phosphatase 2C homolog 1

1

9

High-throughput

0.621

High

917628

MLC1
Myosin light chain 1

1

3

High-throughput

0.621

High

632398

CG11
G1/S-specific cyclin CLN1

1

13

Small-scale

0.618

High

667117

CG22
G2/mitotic-specific cyclin-2

1

6

Small-scale

0.618

High

694168

CDC15
Cell division control protein 15

1

16

Small-scale

0.618

High

718958

CGS5
S-phase entry cyclin-5

1

6

Small-scale

0.618

High

800914

NCB5R
NADH-cytochrome b5 reductase 1

2

2

Small-scale

0.614

High

924365

MDG1
Signal transduction protein MDG1

1

0

High-throughput

0.614

High

760341

BMH2
Protein BMH2

2

17

Small-scale

0.611

High

779017

MYO3
Myosin-3

2

20

Small-scale

0.602

High

1043010

BMS1
Ribosome biogenesis protein BMS1

2

1

Small-scale

0.602

High

546076

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.601

High

818138

SHO1
High osmolarity signaling protein SHO1

2

0

Small-scale

0.588

High

435322

RS3
Small ribosomal subunit protein uS3

2

5

Small-scale

0.584

High

597993

NCPR
NADPH--cytochrome P450 reductase

2

2

Small-scale

0.576

High

797253

HSL7
Protein arginine N-methyltransferase HSL7

1

2

Small-scale

0.552

High

916486

SUT1
Sterol uptake protein 1

1

2

Small-scale

0.552

High

1042993

MYO5
Myosin-5

1

20

High-throughput

0.552

High

819648

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

737031

CDC3
Cell division control protein 3

2

3

Small-scale

0.550

High

739747

SPT16
FACT complex subunit SPT16

2

5

Small-scale

0.550

High

922160

ARE2
Sterol O-acyltransferase 2

2

3

Small-scale

0.543

High

1043007

BUD7
Bud site selection protein 7

2

0

High-throughput

0.541

High

722213

XPO1
Exportin-1

1

13

High-throughput

0.536

High

678050

HSP30
30 kDa heat shock protein

1

0

High-throughput

0.518

High

709955

BMH1
Protein BMH1

1

17

Small-scale

0.515

High

1042996

ERB1
Ribosome biogenesis protein ERB1

1

16

High-throughput

0.515

High

448403

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.513

High

1042835

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

High-throughput

0.513

High

381238

H2B1
Histone H2B.1

1

20

Small-scale

0.501

High

381615

H2B2
Histone H2B.2

1

20

Small-scale

0.501

High

382309

H4
Histone H4

1

4

Small-scale

0.501

High

453994

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.501

High

455588

SYSC
Serine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.501

High

581898

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

600711

SEC2
Rab guanine nucleotide exchange factor SEC2

1

2

High-throughput

0.501

High

677233

SPB1
27S pre-rRNA

1

5

Small-scale

0.501

High

712763

PTP2
Tyrosine-protein phosphatase 2

1

10

High-throughput

0.501

High

726281

ATS1
Protein KTI13

1

4

High-throughput

0.501

High

746664

DRS1
ATP-dependent RNA helicase DRS1

1

10

High-throughput

0.501

High

750769

PRS6A
26S proteasome regulatory subunit 6A

1

8

Small-scale

0.501

High

789813

SOL2
6-phosphogluconolactonase-like protein 2

1

1

High-throughput

0.501

High

796116

IMB2
Importin subunit beta-2

1

8

Small-scale

0.501

High

796672

IST2
Increased sodium tolerance protein 2

1

1

High-throughput

0.501

High

800941

AGM1
Phosphoacetylglucosamine mutase

1

1

High-throughput

0.501

High

815956

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

10

High-throughput

0.501

High

824696

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

836327

BNI1
Protein BNI1

1

1

Small-scale

0.501

High

850564

RSC8
Chromatin structure-remodeling complex protein RSC8

1

4

Small-scale

0.501

High

858124

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.501

High

864272

ALY2
Arrestin-related trafficking adapter 3

1

8

Small-scale

0.501

High

919711

REXO1
RNA exonuclease 1

1

2

High-throughput

0.501

High

925443

RCM1
25S rRNA

1

3

High-throughput

0.501

High

1042994

ASND1
Asparagine synthetase domain-containing protein YML096W

1

1

High-throughput

0.501

High

1042999

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

1

Small-scale

0.501

High

1043001

UBX5
UBX domain-containing protein 5

1

1

High-throughput

0.501

High

1043004

BDF2
Bromodomain-containing factor 2

1

9

High-throughput

0.501

High

1043012

SAS10
Something about silencing protein 10

1

2

High-throughput

0.501

High

1043017

MSB4
GTPase-activating protein MSB4

1

5

High-throughput

0.501

High

1043019

NSI1
RNA polymerase I termination factor

1

7

High-throughput

0.501

High

1043020

YO098
Uncharacterized protein YOL098C

1

8

High-throughput

0.501

High

359059

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

6

High-throughput

0.500

High

359522

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.500

High

367804

ENO1
Enolase 1

1

3

High-throughput

0.500

High

555143

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.500

High

592467

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

739270

PRP21
Pre-mRNA-splicing factor PRP21

1

0

High-throughput

0.486

High

835564

BUD8
Bud site selection protein 8

1

0

High-throughput

0.486

High

1042997

ENT2
Epsin-2

1

1

High-throughput

0.481

High

1043000

RGA2
Rho-type GTPase-activating protein 2

1

13

High-throughput

0.481

High

367502

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.480

High

632206

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.480

High

664345

SSD1
Protein SSD1

1

0

High-throughput

0.480

High

677699

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.480

High

678340

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

Small-scale

0.480

High

740312

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.480

High

744732

RRN6
RNA polymerase I-specific transcription initiation factor RRN6

1

0

High-throughput

0.480

High

790461

PAM1
Protein PAM1

1

0

High-throughput

0.480

High

796487

YBS1
Uncharacterized protein YBR071W

1

0

High-throughput

0.480

High

796825

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.480

High

797220

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.480

High

805781

YHT1
PH domain-containing protein YHR131C

1

0

High-throughput

0.480

High

817431

THO1
Protein THO1

1

0

High-throughput

0.480

High

828617

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.480

High

835550

BUD6
Bud site selection protein 6

1

0

Small-scale

0.480

High

921133

DCP2
m7GpppN-mRNA hydrolase

1

0

Small-scale

0.480

High

923307

DUS1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]

1

0

High-throughput

0.480

High

1043005

MPC54
Meiotic plaque component protein 54

1

0

High-throughput

0.480

High

1043009

YIG1
Protein YIG1

1

0

High-throughput

0.480

High

1043018

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.480

High

1043021

ECM3
Protein ECM3

1

0

High-throughput

0.480

High

432359

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

149932

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

365687

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

436142

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

442087

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

674808

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

680013

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

708023

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

708778

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.479

High

778510

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

779332

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.479

High

792220

GBLP
Small ribosomal subunit protein RACK1

1

13

Small-scale

0.479

High

802362

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

805432

BZZ1
Protein BZZ1

1

9

Small-scale

0.479

High

874501

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

1033536

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1042208

TOM1
E3 ubiquitin-protein ligase TOM1

1

20

High-throughput

0.479

High

1043016

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

809160

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.460

High

864816

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

1043014

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

744718

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

2

High-throughput

0.457

High

797162

AIM3
Altered inheritance of mitochondria protein 3

1

4

High-throughput

0.457

High

798590

UBX7
UBX domain-containing protein 7

1

5

High-throughput

0.457

High

800359

GRPE
GrpE protein homolog, mitochondrial

1

1

High-throughput

0.457

High

801705

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

13

High-throughput

0.457

High

814126

HPH2
Protein HPH2

1

1

High-throughput

0.457

High

817618

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

Small-scale

0.457

High

864744

BBC1
Myosin tail region-interacting protein MTI1

1

5

High-throughput

0.457

High

898924

AVT4
Vacuolar amino acid transporter 4

1

6

High-throughput

0.457

High

1042990

YMD7
Uncharacterized protein YML037C

1

1

High-throughput

0.457

High

1042992

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

Small-scale

0.457

High

1042998

COG4
Conserved oligomeric Golgi complex subunit 4

1

1

Small-scale

0.457

High

1043002

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.457

High

1043013

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.457

High

394857

EF1A
Elongation factor 1-alpha

1

7

High-throughput

0.445

High

453761

PYR1
Multifunctional protein URA2

1

8

High-throughput

0.445

High

510777

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

524982

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

527548

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

742281

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752670

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

810883

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.445

High

410313

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433826

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

455238

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

512622

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.437

High

513193

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

678282

ARE1
Sterol O-acyltransferase 1

1

3

Small-scale

0.437

High

689637

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

753559

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

1043006

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

1043008

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

672173

ERG4
Delta(24(24(1)))-sterol reductase ERG4

2

0

Small-scale

0.320

High

835951

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.288

High

428012

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.261

Low

677834

YCZ0
Uncharacterized protein YCR100C

1

0

High-throughput

0.261

Low

784404

RM36
Large ribosomal subunit protein bL31m

1

0

High-throughput

0.261

Low

793240

YBR3
Uncharacterized protein YBR063C

1

0

High-throughput

0.261

Low

796245

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

High-throughput

0.261

Low

813924

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.261

Low

858516

STB2
Protein STB2

1

0

High-throughput

0.261

Low

1010269

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.261

Low

1042991

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.261

Low

1042995

YMI3
Putative uncharacterized protein YML083C

1

0

High-throughput

0.261

Low

1043003

MRX9
MIOREX complex component 9

1

0

High-throughput

0.261

Low

877891

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025