HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	24981860, 35271311, 30274258
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 351
+	Rn
		1144336 PABP1_RAT (1-636): 0: 579: 99.53		AKT3_RAT (37-343): 8.56e-147: 424: 42.12
+	Hs
		568649 PABP4_HUMAN (1-635): 0: 534: 74.69		KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00
+	Hs
		516724 PABP1_HUMAN (1-636): 0: 582: 100.00		KS6B2_HUMAN (7-351): 3.64e-142: 412: 34.08
+	Hs
		116962 PABP1_HUMAN (1-636): 0: 582: 100.00		SGK1_HUMAN (34-342): 1.03e-85: 267: 42.54
+	Sc
		376578 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		KAPB_YEAST (25-351): 1.99e-145: 417: 49.70
+	Mm
		397204 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		KAPCA_MOUSE (1-351): 4.96e-164: 463: 98.01
+	Mm
		857308 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		KAPCB_MOUSE (1-351): 5.81e-161: 455: 92.31
+	Mm
		554885 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70
+	Hs
		582536 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		KS6B2_HUMAN (7-351): 3.64e-142: 412: 34.08