HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: PAN2 (Q504Q3)
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)
Gene: PAN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	29395067, 17785442, 14583602, 31104843, 23398456
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1202
+	Hs
		1031353 PABP4_HUMAN (1-635): 0: 534: 74.69		PAN2_HUMAN (1-1202): 0: 1136: 100.00
+	Hs
		582323 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		PAN2_HUMAN (1-1202): 0: 1136: 100.00
+	Hs
		516625 PABP1_HUMAN (1-636): 0: 582: 100.00		UBP7_HUMAN (340-1038): 1.3e-89: 315: 12.02
+	Hs
		516747 PABP1_HUMAN (1-636): 0: 582: 100.00		UBP22_HUMAN (462-854): 5.81e-86: 291: 12.30
+	Sc
		376857 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PAN2_YEAST (71-1186): 5.22e-176: 550: 22.50
+	Sc
		376803 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		UTP7_YEAST (35-461): 8e-81: 278: 15.37
+	Hs
		171727 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		WDR46_HUMAN (35-483): 2.12e-94: 317: 12.19
+	Hs
		69565 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		B0UZZ8_HUMAN (35-483): 2.12e-94: 317: 12.19
+	Hs
		582419 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		UBP7_HUMAN (340-1038): 1.3e-89: 315: 12.02
+	Hs
		1220120 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		GOR_HUMAN (951-1156): 1.52e-46: 180: 21.91