HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: PABP2 (Q86U42)
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Gene: PABPN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	23665581
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008143 - poly(A) binding GO:1990904 - ribonucleoprotein complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 306
+	Hs
		516425 PABP1_HUMAN (1-636): 0: 582: 100.00		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516339 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516495 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		516689 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP3_HUMAN (59-260): 1.51e-19: 90.7: 11.82
+	Hs
		853881 PABP4_HUMAN (1-635): 0: 534: 74.69		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Sc
		376818 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		SGN1_YEAST (116-301): 3.31e-32: 121: 25.00
+	Sp
		145447 PABP_SCHPO (2-427): 9.83e-63: 221: 26.41		PAB2_SCHPO (107-255): 3.12e-34: 124: 48.32
+	Sc
		376562 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PABP_YEAST (143-260): 3.27e-19: 89.6: 20.17
+	Sc
		376785 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		HRB1_YEAST (153-268): 1.5e-16: 81.4: 29.51
+	Hs
		1199032 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PABP2_HUMAN (96-306): 9.35e-43: 150: 100.00
+	Sc
		376694 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PUB1_YEAST (165-255): 5.29e-09: 58.8: 18.48
+	Hs
		1119141 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PAP1L_HUMAN (66-260): 2.53e-23: 101: 12.25
+	Hs
		516635 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		680422 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIA1_HUMAN (167-278): 4.88e-19: 88.4: 15.93
+	Hs
		474021 PAB4L_HUMAN (187-380): 1.23e-36: 142: 29.74		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Mm
		665745 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		PABP1_MOUSE (59-260): 4.17e-22: 98.4: 11.33
+	Hs
		516355 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33