Protein: KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)

Gene: KKCC1, CAMKK1
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q8N5S9

Gene Ontology (top 5):
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

885839

KC1E
Casein kinase I isoform epsilon

1

11

High-throughput

0.691

High

1120030

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

17

High-throughput

0.691

High

1121703

SAFB2
Scaffold attachment factor B2

1

2

High-throughput

0.691

High

1158799

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

11

High-throughput

0.691

High

1328476

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

20

High-throughput

0.691

High

1049556

1433F
14-3-3 protein eta

3

19

Small-scale

0.681

High

1157815

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.656

High

1095415

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

Small-scale

0.647

High

246041

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.630

High

730054

1433B
14-3-3 protein beta/alpha

2

18

High-throughput

0.628

High

1328472

TRI11
E3 ubiquitin-protein ligase TRIM11

2

1

High-throughput

0.628

High

1328479

RUVB2
RuvB-like 2

2

2

High-throughput

0.628

High

1328480

RUVB1
RuvB-like 1

2

2

High-throughput

0.628

High

1327080

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.618

High

242278

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.618

High

461706

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468596

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

666998

CCNE1
G1/S-specific cyclin-E1

1

4

High-throughput

0.618

High

1328478

UBQL2
Ubiquilin-2

1

6

High-throughput

0.618

High

691245

1433T
14-3-3 protein theta

2

18

Small-scale

0.611

High

971780

1433E
14-3-3 protein epsilon

2

9

High-throughput

0.611

High

176516

GRRE1
Granule associated Rac and RHOG effector protein 1

2

0

High-throughput

0.602

High

564055

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.589

High

516433

CALM2
Calmodulin-2

1

19

High-throughput

0.575

High

516557

CALM3
Calmodulin-3

1

19

High-throughput

0.575

High

1328475

LPIN3
Phosphatidate phosphatase LPIN3

2

1

High-throughput

0.574

High

860838

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.536

High

966612

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

1008586

NTH
Endonuclease III-like protein 1

1

1

High-throughput

0.536

High

1328474

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

1

High-throughput

0.536

High

301560

WFS1
Wolframin

1

1

High-throughput

0.515

High

361302

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

415719

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.515

High

451215

NFL
Neurofilament light polypeptide

1

6

High-throughput

0.515

High

637632

FLNA
Filamin-A

1

3

High-throughput

0.515

High

791533

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

843765

HD
Huntingtin

1

1

High-throughput

0.515

High

1324563

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.515

High

1328473

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.515

High

49995

IRGM
Immunity-related GTPase family M protein

1

0

High-throughput

0.513

High

249295

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.513

High

593680

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

1098640

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

1247822

PADI6
Inactive protein-arginine deiminase type-6

1

0

High-throughput

0.513

High

1328477

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.513

High

422592

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

954539

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1116537

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.489

High

627992

ANXA7
Annexin A7

1

3

High-throughput

0.479

High

730769

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

1017024

H33
Histone H3.3

1

3

High-throughput

0.479

High

1328481

RNF11
RING finger protein 11

1

3

High-throughput

0.470

High

721725

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.458

High

117246

K7EK07
Histone H3

1

3

High-throughput

0.445

High

106268

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1085134

SCRN1
Secernin-1

1

0

High-throughput

0.426

High

76395

B4DT77
Annexin

1

3

High-throughput

0.407

High

338153

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.279

Low

528694

PPGB
Lysosomal protective protein

1

0

High-throughput

0.279

Low

1239125

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.279

Low

1315449

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025