Protein: KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)

Gene: KKCC2, CAMKK2
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q96RR4

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158164

MK14
Mitogen-activated protein kinase 14

4

18

High-throughput

0.903

High

272401

OBSL1
Obscurin-like protein 1

4

0

High-throughput

0.857

High

930781

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

19

High-throughput

0.811

High

1106050

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

4

High-throughput

0.789

High

1158488

CDC37
Hsp90 co-chaperone Cdc37

1

4

High-throughput

0.691

High

1158805

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

12

High-throughput

0.691

High

1401832

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

1401837

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

11

High-throughput

0.691

High

49576

FEZF1
Fez family zinc finger protein 1

1

0

High-throughput

0.656

High

605784

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

15

Small-scale

0.647

High

1120037

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

18

Small-scale

0.647

High

488261

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

3

High-throughput

0.628

High

930352

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

8

High-throughput

0.628

High

122972

SGK1
Serine/threonine-protein kinase Sgk1

1

15

Small-scale

0.618

High

461839

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468713

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

905651

IRAK1
Interleukin-1 receptor-associated kinase 1

1

9

High-throughput

0.618

High

1095446

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

High-throughput

0.618

High

1115939

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.618

High

1401830

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.618

High

422946

A4
Amyloid-beta precursor protein

2

4

High-throughput

0.602

High

716489

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

890218

HINT1
Adenosine 5'-monophosphoramidase HINT1

2

0

High-throughput

0.602

High

1398329

CEP63
Centrosomal protein of 63 kDa

2

4

High-throughput

0.590

High

231619

PRKY
Putative serine/threonine-protein kinase PRKY

1

19

High-throughput

0.575

High

516368

CALM1
Calmodulin-1

1

18

High-throughput

0.575

High

516447

CALM2
Calmodulin-2

1

18

High-throughput

0.575

High

516576

CALM3
Calmodulin-3

1

18

High-throughput

0.575

High

1401828

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

17

High-throughput

0.575

High

1401829

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.561

High

318860

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.553

High

220970

XPOT
Exportin-T

1

1

High-throughput

0.536

High

555836

MYL4
Myosin light chain 4

1

15

High-throughput

0.536

High

637694

FLNA
Filamin-A

1

5

High-throughput

0.536

High

661321

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

2

High-throughput

0.536

High

730844

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

1008296

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.536

High

1111477

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

7

High-throughput

0.536

High

1125385

FLNC
Filamin-C

1

5

High-throughput

0.536

High

1130156

SMC1A
Structural maintenance of chromosomes protein 1A

1

3

High-throughput

0.536

High

1280724

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.536

High

1281004

FLIP1
Filamin-A-interacting protein 1

1

7

High-throughput

0.536

High

1286784

KAISO
Transcriptional regulator Kaiso

1

1

High-throughput

0.536

High

1365733

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.536

High

1383818

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1401835

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.536

High

1401836

SMC3
Structural maintenance of chromosomes protein 3

1

3

High-throughput

0.536

High

474916

VIME
Vimentin

1

9

High-throughput

0.515

High

48749

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

334228

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

348259

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

870970

IREB2
Iron-responsive element-binding protein 2

1

0

High-throughput

0.513

High

1389066

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

1401833

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1401838

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

384523

CRYAA
Alpha-crystallin A chain

1

8

High-throughput

0.501

High

861737

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

7

High-throughput

0.501

High

916329

TXTP
Tricarboxylate transport protein, mitochondrial

1

6

High-throughput

0.489

High

1401831

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.489

High

1401834

DNAI2
Dynein axonemal intermediate chain 2

1

3

High-throughput

0.489

High

344005

HS74L
Heat shock 70 kDa protein 4L

1

6

High-throughput

0.479

High

284343

GEMI
Geminin

1

0

High-throughput

0.458

High

1200143

BOREA
Borealin

1

0

High-throughput

0.458

High

106513

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1040194

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

7

High-throughput

0.437

High

1211441

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1254124

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

1177069

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025