HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: RFC2 (P35250)
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)
Gene: RFC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.946

The method score is based on:

Property Details
Experiments 26496610, 9228079, 8093561, 12171929, 35271311, 24958773
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~PCNA_C, AAA~PCNA_N
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0019899 - enzyme binding
GO:1900264 - positive regulation of DNA-directed DNA polymerase activity
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 261
Hs

1 354
+ Bt
+ Hs
+ Hs
+ Dm
+ Dm
+ Bt
+ Hs
+ Sc
+ Dm
+ Sc
+ Sc
+ Sc

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Last updated: 15 Jul 2024