HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: KMT5A (Q9NQR1)
N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)
Gene: KMT5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	27462463, 22556262, 26666832, 18319261, 18166648, 21035370
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 393
+	Hs
		517272 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		EZH2_HUMAN (134-386): 6.9e-64: 219: 18.25
+	Hs
		331710 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		NSD2_HUMAN (134-378): 2.27e-60: 213: 22.13
+	Dm
		572207 PCNA_DROME (1-259): 1.18e-122: 351: 71.04		KMT5A_DROME (34-391): 2.76e-61: 211: 31.00
+	Mm
		222459 PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94		SUV91_MOUSE (127-379): 3.23e-59: 199: 21.48
+	At
		1258482 PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75		ATXR5_ARATH (36-388): 1.06e-63: 210: 18.59
+	Ce
		137354 PCNA_CAEEL (1-260): 8.65e-107: 311: 47.89		KMT5A_CAEEL (175-391): 2.45e-61: 199: 40.72
+	Hs
		517265 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		SETB1_HUMAN (205-300): 8.9e-16: 81.4: 14.56