HitPredict

Interactor 1: K2C3 (P12035)
Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)
Gene: KRT3

Interactor 2: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0030855 - epithelial cell differentiation GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 628 Hs			1 431
+	Hs
		729114 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C39_HUMAN (2-430): 3.23e-153: 444: 50.11
+	Hs
		280536 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		280508 K2C8_HUMAN (170-550): 6.7e-164: 479: 65.35		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		729085 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KT33B_HUMAN (23-429): 5.43e-111: 333: 58.48
+	Hs
		444326 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C19_HUMAN (82-397): 4.55e-103: 313: 51.90
+	Hs
		729070 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81
+	Hs
		445010 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C16_HUMAN (85-412): 2.56e-96: 298: 51.52
+	Hs
		579997 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C15_HUMAN (88-401): 4.65e-95: 295: 52.38
+	Hs
		49556 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		A1A4E9_HUMAN (80-411): 7.5e-95: 294: 50.75
+	Hs
		531451 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C13_HUMAN (80-411): 1.72e-94: 293: 50.75
+	Hs
		729145 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KRT35_HUMAN (2-427): 4.45e-87: 274: 59.35
+	Hs
		280777 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KRT36_HUMAN (7-407): 2.14e-84: 267: 63.34
+	Hs
		729086 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1H2_HUMAN (1-426): 1.69e-83: 265: 55.63
+	Hs
		729113 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1C40_HUMAN (1-431): 4.93e-84: 265: 100.00
+	Hs
		49549 K2C8_HUMAN (170-550): 6.7e-164: 479: 65.35		A1A4E9_HUMAN (80-411): 7.5e-95: 294: 50.75
+	Hs
		280955 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KRT38_HUMAN (1-430): 8.86e-77: 247: 49.77
+	Hs
		280859 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		KRT37_HUMAN (1-429): 1.93e-75: 243: 48.25
+	Hs
		729096 K22E_HUMAN (170-516): 5.85e-174: 510: 72.49		K1H1_HUMAN (48-425): 7.13e-75: 241: 63.23
+	Hs
		280770 K2C8_HUMAN (170-550): 6.7e-164: 479: 65.35		KRT36_HUMAN (7-407): 2.14e-84: 267: 63.34
+	Hs
		280845 K2C8_HUMAN (170-550): 6.7e-164: 479: 65.35		KRT37_HUMAN (1-429): 1.93e-75: 243: 48.25