HitPredict

Interactor 1: MYCL (P12524)
Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)
Gene: MYCL

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 463
+	Hs
		519741 MYCL_HUMAN (1-364): 4.25e-117: 345: 100.00		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Mm
		348451 MYC_MOUSE (1-362): 4.56e-78: 248: 29.98		RUVB2_MOUSE (1-463): 0: 718: 99.57
+	Hs
		348267 MYC_HUMAN (1-362): 1e-76: 245: 29.75		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		348273 MYC_HUMAN (1-362): 1e-76: 245: 29.75		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		738999 SRBP1_HUMAN (35-363): 5.77e-47: 173: 14.29		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Dm
		1358878 MYC_DROME (112-364): 2.04e-32: 130: 20.16		RUVB2_DROME (6-458): 0: 681: 78.15
+	Hs
		898221 MAX_HUMAN (278-362): 3.89e-21: 90.8: 34.12		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Dm
		1366597 MYC_DROME (112-364): 2.04e-32: 130: 20.16		RUVB1_DROME (8-452): 0: 619: 44.32
+	Hs
		898222 MAX_HUMAN (278-362): 3.89e-21: 90.8: 34.12		RUVB1_HUMAN (8-451): 0: 655: 42.67