HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	11416139, 33640491
Identification Methods	two hybrid, affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 920 Hs			1 197
+	Hs
		519968 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		519966 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		519967 ANDR_HUMAN (1-920): 0: 966: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		395963 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		395964 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		976887 ERR3_HUMAN (467-904): 1.4e-116: 365: 21.54		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		403995 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		833920 HNF4A_HUMAN (536-906): 1e-104: 335: 22.85		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		833925 HNF4A_HUMAN (536-906): 1e-104: 335: 22.85		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00