HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23403292
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 772
+	Hs
		395963 ESR1_HUMAN (1-595): 0: 599: 100.00		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		396014 ESR1_HUMAN (1-595): 0: 599: 100.00		STRN3_HUMAN (4-768): 3.73e-103: 337: 13.55
+	Hs
		833920 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		396885 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (208-690): 5.52e-76: 256: 11.61
+	Hs
		395850 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB2_HUMAN (369-646): 6.82e-46: 169: 16.90
+	Hs
		396978 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB4_HUMAN (440-646): 8.52e-40: 151: 18.96
+	Hs
		395848 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB1_HUMAN (567-770): 2.96e-38: 147: 17.62
+	Hs
		1092909 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		STRN3_HUMAN (4-768): 3.73e-103: 337: 13.55
+	Hs
		396440 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (235-559): 7.52e-32: 128: 8.71
+	Hs
		395811 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		209183 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP4_HUMAN (555-763): 6.51e-12: 70.9: 28.24
+	Hs
		1367207 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		TBL1R_HUMAN (208-690): 5.52e-76: 256: 11.61
+	Hs
		597366 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		GBB3_HUMAN (368-646): 7.03e-46: 169: 17.31
+	Hs
		984224 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		GBB2_HUMAN (369-646): 6.82e-46: 169: 16.90
+	Hs
		983545 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		GBB1_HUMAN (567-770): 2.96e-38: 147: 17.62
+	Hs
		1367405 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		NLE1_HUMAN (651-771): 5.85e-34: 138: 16.92
+	Hs
		965126 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		833911 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		209311 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PRP4_HUMAN (555-763): 6.51e-12: 70.9: 28.24
+	Hs
		261380 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		TBL1X_HUMAN (680-768): 3.22e-13: 75.2: 17.31