HitPredict

Interactor 1: YPK1 (P12688)
Serine/threonine-protein kinase YPK1 (EC 2.7.11.1) (Sphingosine-like immunosuppressant resistant protein 2) (Yeast protein kinase 1)
Gene: YPK1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	31399574, 37295430, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 680 Sc			1 705
+	Sc
		365679 YPK1_YEAST (1-680): 0: 651: 100.00		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		543156 YPK2_YEAST (1-679): 0: 607: 67.34		HSC82_YEAST (1-705): 0: 977: 100.00
+	Mm
		513660 AKT1_MOUSE (203-666): 1.02e-163: 480: 34.96		HS90B_MOUSE (5-705): 0: 1025: 61.57
+	Hs
		437928 AKT2_HUMAN (203-666): 1.49e-164: 482: 33.55		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Bt
		964601 AKT1_BOVIN (203-666): 1.52e-164: 482: 34.75		HS90B_BOVIN (5-705): 0: 1022: 61.15
+	Hs
		437927 AKT1_HUMAN (203-666): 6.7e-164: 481: 34.75		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		438633 AKT3_HUMAN (235-666): 9.09e-162: 475: 36.51		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		431573 AKT2_HUMAN (203-666): 1.49e-164: 482: 33.55		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Rn
		812703 AKT1_RAT (203-666): 7.55e-164: 481: 34.96		HS90A_RAT (4-705): 0: 1014: 60.59
+	Hs
		431572 AKT1_HUMAN (203-666): 6.7e-164: 481: 34.75		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		437869 KPCA_HUMAN (196-668): 3.1e-157: 471: 30.04		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Mm
		432411 AKT1_MOUSE (203-666): 1.02e-163: 480: 34.96		HS90A_MOUSE (4-705): 0: 1012: 60.59
+	Hs
		437907 KPCL_HUMAN (309-668): 4.36e-156: 468: 38.90		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		432376 AKT3_HUMAN (235-666): 9.09e-162: 475: 36.51		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431510 KPCA_HUMAN (196-668): 3.1e-157: 471: 30.04		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431548 KPCL_HUMAN (309-668): 4.36e-156: 468: 38.90		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		408527 KPCB_HUMAN (196-668): 9.72e-155: 464: 30.27		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		538122 AKT1_HUMAN (203-666): 6.7e-164: 481: 34.75		ENPL_HUMAN (3-680): 0: 893: 47.10
+	Hs
		538446 AKT3_HUMAN (235-666): 9.09e-162: 475: 36.51		ENPL_HUMAN (3-680): 0: 893: 47.10
+	Hs
		538091 KPCA_HUMAN (196-668): 3.1e-157: 471: 30.04		ENPL_HUMAN (3-680): 0: 893: 47.10