Protein: SQSTM
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)

Gene: SQSTM, Sqstm1
Organism: Mus musculus
Interactions: 98
UniProt ID: Q64337

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000407 - phagophore assembly site
GO:0000423 - mitophagy
GO:0000425 - pexophagy
GO:0000932 - P-body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989563

MK01
Mitogen-activated protein kinase 1

2

6

Small-scale

0.799

High

266961

ULK1
Serine/threonine-protein kinase ULK1

2

11

Small-scale

0.776

High

1225683

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

2

6

Small-scale

0.770

High

1225651

SQSTM
Sequestosome-1

2

12

Small-scale

0.755

High

1225669

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

6

14

Small-scale

0.734

High

509102

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

5

14

Small-scale

0.714

High

1224627

MK03
Mitogen-activated protein kinase 3

1

6

Small-scale

0.691

High

1225654

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

4

4

Small-scale

0.687

High

1225686

KEAP1
Kelch-like ECH-associated protein 1

3

6

Small-scale

0.681

High

1021387

NBR1
Next to BRCA1 gene 1 protein

1

2

Small-scale

0.681

High

1190021

NTRK1
High affinity nerve growth factor receptor

3

11

Small-scale

0.662

High

999846

TRAF6
TNF receptor-associated factor 6

3

15

Small-scale

0.650

High

108717

G3X9H5
Huntingtin

3

3

Small-scale

0.640

High

705875

KPCD
Protein kinase C delta type

1

13

Small-scale

0.618

High

1040009

KPCZ
Protein kinase C zeta type

1

14

Small-scale

0.618

High

1225663

TRIB3
Tribbles homolog 3

1

6

Small-scale

0.618

High

1222279

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

8

Small-scale

0.617

High

313449

CASP8
Caspase-8

2

4

Small-scale

0.584

High

467763

SODC
Superoxide dismutase [Cu-Zn]

2

1

Small-scale

0.584

High

1225658

A16L1
Autophagy-related protein 16-1

2

6

Small-scale

0.584

High

1225666

NLRP3
NACHT, LRR and PYD domains-containing protein 3

2

5

Small-scale

0.584

High

1225668

AIM2
Interferon-inducible protein AIM2

2

2

Small-scale

0.584

High

1225673

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

14

Small-scale

0.584

High

584838

TR30A
Tripartite motif-containing protein 30A

1

6

Small-scale

0.561

High

1225662

OPTN
Optineurin

1

9

Small-scale

0.550

High

945741

SESN2
Sestrin-2

1

2

Small-scale

0.536

High

663033

GRIA1
Glutamate receptor 1

1

4

Small-scale

0.515

High

704498

RXRA
Retinoic acid receptor RXR-alpha

1

8

Small-scale

0.515

High

871151

VDR
Vitamin D3 receptor

1

6

Small-scale

0.515

High

1225671

NRIF1
Neurotrophin receptor-interacting factor 1

1

1

Small-scale

0.515

High

844158

HD
Huntingtin

1

3

Small-scale

0.500

High

108268

TRI55
Tripartite motif-containing 55

1

15

Small-scale

0.479

High

313351

COR1A
Coronin-1A

1

4

High-throughput

0.479

High

382492

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

581993

NTRK2
BDNF/NT-3 growth factors receptor

1

11

Small-scale

0.479

High

618515

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

628503

VIME
Vimentin

1

6

Small-scale

0.479

High

648061

MYD88
Myeloid differentiation primary response protein MyD88

1

2

Small-scale

0.479

High

655048

CXA1
Gap junction alpha-1 protein

1

3

Small-scale

0.479

High

660992

IRF8
Interferon regulatory factor 8

1

2

Small-scale

0.479

High

663111

GRIA2
Glutamate receptor 2

1

4

Small-scale

0.479

High

697723

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.479

High

712085

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

2

Small-scale

0.479

High

753181

MMP2
72 kDa type IV collagenase

1

3

Small-scale

0.479

High

772561

IRS1
Insulin receptor substrate 1

1

8

Small-scale

0.479

High

834259

MMP9
Matrix metalloproteinase-9

1

3

Small-scale

0.479

High

861882

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.479

High

972635

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

999091

1433F
14-3-3 protein eta

1

10

Small-scale

0.479

High

1000299

ELAV1
ELAV-like protein 1

1

5

Small-scale

0.479

High

1021491

SNAI2
Zinc finger protein SNAI2

1

4

Small-scale

0.479

High

1021907

SMN
Survival motor neuron protein

1

2

Small-scale

0.479

High

1034863

SNAI1
Zinc finger protein SNAI1

1

5

Small-scale

0.479

High

1045976

TF65
Transcription factor p65

1

2

Small-scale

0.479

High

1180423

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

3

Small-scale

0.479

High

1190387

TAXB1
Tax1-binding protein 1 homolog

1

7

Small-scale

0.479

High

1221459

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

6

Small-scale

0.479

High

1221621

KLF2
Krueppel-like factor 2

1

3

Small-scale

0.479

High

1221633

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

9

Small-scale

0.479

High

1222114

KLF3
Krueppel-like factor 3

1

5

Small-scale

0.479

High

1225473

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

3

High-throughput

0.479

High

1225653

Q7TMG8
Glioblastoma amplified sequence

1

2

Small-scale

0.479

High

1225655

SAM50
Sorting and assembly machinery component 50 homolog

1

2

Small-scale

0.479

High

1225657

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

3

Small-scale

0.479

High

1225660

MIC60
MICOS complex subunit Mic60

1

5

Small-scale

0.479

High

1225667

S25A3
Solute carrier family 25 member 3

1

3

Small-scale

0.479

High

1225675

TM160
Transmembrane protein 160

1

1

Small-scale

0.479

High

1225676

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

Small-scale

0.479

High

1225677

ASC
Apoptosis-associated speck-like protein containing a CARD

1

4

Small-scale

0.479

High

1225679

CUL3
Cullin-3

1

6

Small-scale

0.479

High

1225680

LIMD1
LIM domain-containing protein 1

1

13

Small-scale

0.479

High

1225682

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

1225684

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

1

Small-scale

0.479

High

1225685

GRIA3
Glutamate receptor 3

1

4

Small-scale

0.470

High

949051

RUVB1
RuvB-like 1

1

0

Small-scale

0.458

High

1021211

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.458

High

1063098

GATA4
Transcription factor GATA-4

1

0

Small-scale

0.458

High

1188243

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

1222416

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1225670

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

Small-scale

0.458

High

1225672

LTMD1
LETM1 domain-containing protein 1

1

0

Small-scale

0.458

High

1225674

TECR
Very-long-chain enoyl-CoA reductase

1

0

Small-scale

0.458

High

1225661

FTM
Protein fantom

1

4

High-throughput

0.445

High

1225664

RAB38
Ras-related protein Rab-38

1

6

High-throughput

0.445

High

540220

FINC
Fibronectin

1

5

Small-scale

0.437

High

732103

LA
Lupus La protein homolog

1

6

Small-scale

0.437

High

969109

PRS8
26S proteasome regulatory subunit 8

1

11

Small-scale

0.437

High

983422

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

5

Small-scale

0.437

High

1032695

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

Small-scale

0.437

High

1225656

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

2

High-throughput

0.437

High

1225659

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

3

Small-scale

0.437

High

1225665

ANGL8
Angiopoietin-like protein 8

1

1

Small-scale

0.437

High

1225678

XPO7
Exportin-7

1

7

High-throughput

0.407

High

312279

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.249

Low

1223865

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.249

Low

1225652

TEDC2
Tubulin epsilon and delta complex protein 2

1

0

High-throughput

0.249

Low

1225681

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025