HitPredict

Interactor 1: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Interactor 2: GNA12 (Q03113)
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
Gene: GNA12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	22609986, 24114843
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0032006 - regulation of TOR signaling GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 381
+	Hs
		418581 BRAF_HUMAN (3-604): 0: 537: 54.78		GNAI2_HUMAN (25-380): 2.31e-171: 483: 39.78
+	Gg
		893465 BRAF_CHICK (3-604): 0: 535: 55.34		GNAI2_CHICK (25-380): 8.03e-171: 482: 39.50
+	Hs
		400621 RAF1_HUMAN (12-606): 0: 527: 60.27		GNAI1_HUMAN (25-380): 6.79e-173: 487: 40.34
+	Mm
		475859 BRAF_MOUSE (3-604): 0: 535: 54.53		GNAI2_MOUSE (25-380): 1.11e-169: 479: 40.06
+	Hs
		578393 BRAF_HUMAN (3-604): 0: 537: 54.78		GNA11_HUMAN (22-380): 1.29e-167: 474: 42.34
+	Mm
		700380 BRAF_MOUSE (3-604): 0: 535: 54.53		GNAI3_MOUSE (25-380): 1.48e-168: 476: 40.90
+	Hs
		400097 RAF1_HUMAN (12-606): 0: 527: 60.27		GNAI2_HUMAN (25-380): 2.31e-171: 483: 39.78