Protein: BRAF
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf)

Gene: BRAF
Organism: Mus musculus
Interactions: 75
UniProt ID: P28028

Gene Ontology (top 5):
GO:0002318 - myeloid progenitor cell differentiation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700376

RAF1
RAF proto-oncogene serine/threonine-protein kinase

4

18

Small-scale

0.873

High

700339

1433Z
14-3-3 protein zeta/delta

3

20

Small-scale

0.829

High

700327

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

Small-scale

0.775

High

700343

1433F
14-3-3 protein eta

2

20

Small-scale

0.775

High

700351

RASH
GTPase HRas

2

20

Small-scale

0.775

High

700353

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

20

Small-scale

0.775

High

700342

1433T
14-3-3 protein theta

2

20

Small-scale

0.757

High

97715

E9PWZ6
Myosin IXb

1

10

High-throughput

0.618

High

107125

F8VQ29
IQ motif containing GTPase activating protein 3

1

20

High-throughput

0.618

High

267032

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

411148

ARAF
Serine/threonine-protein kinase A-Raf

1

15

High-throughput

0.618

High

462095

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

465806

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

543011

CDK1
Cyclin-dependent kinase 1

1

11

High-throughput

0.618

High

700332

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

High-throughput

0.618

High

700334

1433E
14-3-3 protein epsilon

1

19

High-throughput

0.618

High

700336

RAN
GTP-binding nuclear protein Ran

1

17

High-throughput

0.618

High

700344

CDK2
Cyclin-dependent kinase 2

1

18

High-throughput

0.618

High

700349

CDC37
Hsp90 co-chaperone Cdc37

1

12

High-throughput

0.618

High

700350

KSR1
Kinase suppressor of Ras 1

1

17

Small-scale

0.618

High

700361

CPNE3
Copine-3

1

9

High-throughput

0.618

High

700362

DOCK1
Dedicator of cytokinesis protein 1

1

5

High-throughput

0.618

High

700369

SNX9
Sorting nexin-9

1

6

High-throughput

0.618

High

700373

RAP1B
Ras-related protein Rap-1b

1

20

High-throughput

0.618

High

700377

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

700381

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

15

High-throughput

0.618

High

700367

RAB38
Ras-related protein Rab-38

1

11

High-throughput

0.575

High

700354

MYOF
Myoferlin

1

6

High-throughput

0.553

High

204270

PHB2
Prohibitin-2

1

8

High-throughput

0.479

High

446488

G6PI
Glucose-6-phosphate isomerase

1

3

High-throughput

0.479

High

456907

ANXA2
Annexin A2

1

11

High-throughput

0.479

High

475859

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

17

High-throughput

0.479

High

627456

BIP
Endoplasmic reticulum chaperone BiP

1

18

High-throughput

0.479

High

628481

VIME
Vimentin

1

8

High-throughput

0.479

High

670046

MCM3
DNA replication licensing factor MCM3

1

10

High-throughput

0.479

High

700328

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

700329

ANXA5
Annexin A5

1

11

High-throughput

0.479

High

700331

IF5
Eukaryotic translation initiation factor 5

1

3

High-throughput

0.479

High

700333

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

High-throughput

0.479

High

700335

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

13

High-throughput

0.479

High

700337

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

700338

DNJA1
DnaJ homolog subfamily A member 1

1

14

High-throughput

0.479

High

700340

PHB1
Prohibitin 1

1

8

High-throughput

0.479

High

700341

CSK2B
Casein kinase II subunit beta

1

6

High-throughput

0.479

High

700345

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.479

High

700346

PLD2
Phospholipase D2

1

2

High-throughput

0.479

High

700347

MSHR
Melanocyte-stimulating hormone receptor

1

1

High-throughput

0.479

High

700348

Q5SV02
DNA repair protein RAD50

1

17

High-throughput

0.479

High

700352

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

700355

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.479

High

700357

FMNL3
Formin-like protein 3

1

7

High-throughput

0.479

High

700358

FACD2
Fanconi anemia group D2 protein homolog

1

4

High-throughput

0.479

High

700363

WDR26
WD repeat-containing protein 26

1

13

High-throughput

0.479

High

700366

COPA
Coatomer subunit alpha

1

11

High-throughput

0.479

High

700370

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

3

High-throughput

0.479

High

700371

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

700372

ATD3A
ATPase family AAA domain-containing protein 3A

1

12

High-throughput

0.479

High

700374

DJB11
DnaJ homolog subfamily B member 11

1

14

High-throughput

0.479

High

700375

WDR6
tRNA

1

17

High-throughput

0.479

High

700378

PGAM1
Phosphoglycerate mutase 1

1

2

High-throughput

0.479

High

700379

AKAP8
A-kinase anchor protein 8

1

5

High-throughput

0.479

High

700380

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

18

High-throughput

0.479

High

700382

BAG3
BAG family molecular chaperone regulator 3

1

2

Small-scale

0.479

High

700384

GNAS3
Neuroendocrine secretory protein 55

1

0

High-throughput

0.458

High

59179

A2A9M5
Dedicator of cytokinesis 7

1

5

High-throughput

0.437

High

62342

A4FUW1
Regulatory-associated protein of mTOR

1

15

High-throughput

0.437

High

98249

E9Q9B7
Kinase D-interacting substrate of 220 kDa

1

12

High-throughput

0.437

High

700330

DHI2
11-beta-hydroxysteroid dehydrogenase type 2

1

6

High-throughput

0.437

High

700356

ECM29
Proteasome adapter and scaffold protein ECM29

1

12

High-throughput

0.437

High

700359

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

11

High-throughput

0.437

High

700360

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

2

High-throughput

0.437

High

700365

Q8CHD7
MKIAA0678 protein

1

16

High-throughput

0.437

High

700368

SGPL1
Sphingosine-1-phosphate lyase 1

1

4

High-throughput

0.437

High

700383

DJB12
DnaJ homolog subfamily B member 12

1

13

High-throughput

0.437

High

700364

GRAM4
GRAM domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025