HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 447
+	Hs
		368893 ACTN1_HUMAN (1-892): 0: 697: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		521591 ACTN1_HUMAN (1-892): 0: 697: 100.00		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		211456 ACTN4_HUMAN (11-892): 0: 642: 86.74		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		211472 ACTN4_HUMAN (11-892): 0: 642: 86.74		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		211518 ACTN4_HUMAN (11-892): 0: 642: 86.74		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		211477 ACTN4_HUMAN (11-892): 0: 642: 86.74		VDR_HUMAN (95-446): 9.2e-109: 329: 32.21
+	Hs
		211633 ACTN4_HUMAN (11-892): 0: 642: 86.74		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		993279 ACTN3_HUMAN (18-892): 0: 642: 78.51		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		265854 ACTN2_HUMAN (10-892): 0: 640: 80.29		NR1I2_HUMAN (75-445): 8.74e-49: 174: 29.67
+	Hs
		369420 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		320227 SPTN4_HUMAN (173-588): 8.58e-09: 62: 10.82		ERR2_HUMAN (9-446): 3.62e-117: 351: 25.23
+	Hs
		164649 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69