HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: SYNPO (Q8N3V7)
Synaptopodin
Gene: SYNPO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	26496610, 30021884
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030018 - Z disc
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 929
+	Hs
		211613 ACTN4_HUMAN (11-892): 0: 642: 86.74		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		521616 ACTN1_HUMAN (1-892): 0: 697: 100.00		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		993296 ACTN3_HUMAN (18-892): 0: 642: 78.51		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		725700 ACTN2_HUMAN (10-892): 0: 640: 80.29		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		521599 ACTN1_HUMAN (1-892): 0: 697: 100.00		CIC_HUMAN (71-922): 9.17e-10: 65.1: 8.24
+	Hs
		725714 ACTN2_HUMAN (10-892): 0: 640: 80.29		SYNP2_HUMAN (450-925): 1.51e-25: 116: 18.90
+	Hs
		164638 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		963367 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		963358 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		MICA3_HUMAN (231-870): 4.24e-27: 121: 12.97
+	Dm
		54271 A1Z9I8_DROME (236-822): 1.49e-11: 70.8: 10.32		Q9VLS7_DROME (7-866): 6.18e-15: 82: 9.37
+	Hs
		963398 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		CIC_HUMAN (71-922): 9.17e-10: 65.1: 8.24