HitPredict

Interactor 1: GROA (P12850)
Growth-regulated alpha protein (C-X-C motif chemokine 1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Cleaved into: KC(5-72) (Hematopoietic synergistic factor) (HSF) (KC-T)]
Gene: Cxcl1

Interactor 2: CXCR2 (P35343)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (CD antigen CD182)
Gene: CXCR2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	7890604, 8662882
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 96 Mm			1 359
+	Mm
		500672 CXCL2_MOUSE (18-91): 8.73e-29: 100: 68.92		CXCR2_MOUSE (1-348): 4.87e-83: 258: 100.00
+	Hs
		587767 CXCL2_HUMAN (2-92): 5.29e-29: 101: 64.84		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		364080 PLF4_HUMAN (30-92): 2.07e-22: 85.1: 47.62		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		625748 CXCL5_HUMAN (22-93): 3.56e-27: 97.4: 52.78		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		364105 CXL10_HUMAN (4-92): 5.81e-21: 81.2: 25.28		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		364042 CXCL7_HUMAN (30-93): 2.32e-26: 95.9: 65.63		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		830623 CXCL9_HUMAN (23-89): 1.83e-20: 80.9: 39.71		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		448988 GROA_HUMAN (27-91): 7.36e-26: 94: 70.77		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		587786 CXCL3_HUMAN (27-91): 3.25e-25: 92: 69.23		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		625758 CXCL6_HUMAN (22-92): 1.02e-24: 91.3: 45.07		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		486185 IL8_HUMAN (28-92): 7.49e-23: 85.9: 53.03		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		625736 CXCL5_HUMAN (22-93): 3.56e-27: 97.4: 52.78		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		364041 CXCL7_HUMAN (30-93): 2.32e-26: 95.9: 65.63		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		448987 GROA_HUMAN (27-91): 7.36e-26: 94: 70.77		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		625737 CXCL6_HUMAN (22-92): 1.02e-24: 91.3: 45.07		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		486184 IL8_HUMAN (28-92): 7.49e-23: 85.9: 53.03		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Mm
		291525 CXCL9_MOUSE (4-89): 4e-26: 95.1: 34.48		CXCR3_MOUSE (68-332): 2.68e-55: 186: 39.63
+	Mm
		291524 CXL10_MOUSE (1-92): 2.41e-24: 89.7: 28.72		CXCR3_MOUSE (68-332): 2.68e-55: 186: 39.63
+	Hs
		364107 CXL10_HUMAN (4-92): 5.81e-21: 81.2: 25.28		CCR3_HUMAN (53-324): 6.24e-38: 140: 33.70
+	Hs
		849615 CXCL9_HUMAN (23-89): 1.83e-20: 80.9: 39.71		CCR3_HUMAN (53-324): 6.24e-38: 140: 33.70