HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.764

The method score is based on:

Property Details
Experiments 29899407, 18996392, 11994282, 22203672, 10829062, 17094785, 7782294, 31120930, 12941616, 17141222, 19861161, 15135048, 16636290, 18273061
Identification Methods affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, isothermal titration calorimetry, competition binding, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007165 - signal transduction
GO:0035635 - entry of bacterium into host cell
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 536
Hs

1 906
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024