Protein: COT2
COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)

Gene: COT2, NR2F2
Organism: Homo sapiens
Interactions: 140
UniProt ID: P24468

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001893 - maternal placenta development
GO:0001937 - negative regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

522769

NR2F6
Nuclear receptor subfamily 2 group F member 6

4

19

Small-scale

0.903

High

403830

GCR
Glucocorticoid receptor

1

19

Small-scale

0.740

High

220473

RNF13
E3 ubiquitin-protein ligase RNF13

3

4

High-throughput

0.667

High

639353

5NTD
5'-nucleotidase

3

1

High-throughput

0.667

High

665148

S39A9
Zinc transporter ZIP9

3

2

High-throughput

0.662

High

390275

VTDB
Vitamin D-binding protein

2

2

High-throughput

0.628

High

665067

AKT1
RAC-alpha serine/threonine-protein kinase

2

13

High-throughput

0.628

High

665068

AKT2
RAC-beta serine/threonine-protein kinase

2

14

High-throughput

0.628

High

665073

PI2R
Prostacyclin receptor

2

2

High-throughput

0.628

High

665121

GLMP
Glycosylated lysosomal membrane protein

2

1

High-throughput

0.628

High

665152

SHPK
Sedoheptulokinase

2

2

High-throughput

0.628

High

665158

SALL2
Sal-like protein 2

2

6

High-throughput

0.628

High

665065

COT2
COUP transcription factor 2

1

20

Small-scale

0.621

High

395506

ESR1
Estrogen receptor

1

20

High-throughput

0.618

High

665078

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

Small-scale

0.618

High

665124

ESR2
Estrogen receptor beta

1

20

High-throughput

0.618

High

262209

SCN2B
Sodium channel regulatory subunit beta-2

2

2

High-throughput

0.611

High

190704

MPPD1
Metallophosphoesterase domain-containing protein 1

3

5

High-throughput

0.609

High

332619

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.609

High

665157

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

3

2

High-throughput

0.609

High

665116

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

268915

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

3

6

High-throughput

0.599

High

640102

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.578

High

561900

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.574

High

665069

CD70
CD70 antigen

2

2

High-throughput

0.574

High

665071

APJ
Apelin receptor

2

5

High-throughput

0.574

High

665072

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

3

High-throughput

0.574

High

665081

VMAT1
Chromaffin granule amine transporter

2

2

High-throughput

0.574

High

665117

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

2

High-throughput

0.574

High

665125

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

4

High-throughput

0.574

High

665150

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

9

High-throughput

0.574

High

665140

BC11A
BCL11 transcription factor A

1

12

Small-scale

0.573

High

190043

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.561

High

665110

FOXP4
Forkhead box protein P4

1

20

Small-scale

0.561

High

665141

FOXP1
Forkhead box protein P1

1

20

Small-scale

0.561

High

665090

SLAF1
Signaling lymphocytic activation molecule

2

4

High-throughput

0.558

High

665108

SV2A
Synaptic vesicle glycoprotein 2A

2

2

High-throughput

0.549

High

665101

TRIP4
Activating signal cointegrator 1

1

3

High-throughput

0.541

High

155232

AGRB1
Adhesion G protein-coupled receptor B1

1

2

High-throughput

0.536

High

166120

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

323963

CSTN1
Calsyntenin-1

1

4

High-throughput

0.536

High

346856

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

348369

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.536

High

377969

TNFA
Tumor necrosis factor

1

2

High-throughput

0.536

High

388159

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

486966

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.536

High

665066

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.536

High

665070

CD80
T-lymphocyte activation antigen CD80

1

5

High-throughput

0.536

High

665074

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.536

High

665075

KI67
Proliferation marker protein Ki-67

1

12

High-throughput

0.536

High

665088

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

665100

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.536

High

665106

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.536

High

665107

SO4C1
Solute carrier organic anion transporter family member 4C1

1

1

High-throughput

0.536

High

665113

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

665122

MADD
MAP kinase-activating death domain protein

1

3

High-throughput

0.536

High

665093

SMAD4
Mothers against decapentaplegic homolog 4

1

10

Small-scale

0.534

High

665084

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

665111

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

665112

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

665123

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.513

High

665139

HYCCI
Hyccin

1

0

High-throughput

0.513

High

665143

HIPK3
Homeodomain-interacting protein kinase 3

1

19

High-throughput

0.508

High

581623

MYOD1
Myoblast determination protein 1

1

7

Small-scale

0.501

High

665094

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

665134

PHB2
Prohibitin-2

1

9

Small-scale

0.501

High

133227

P2Y10
Putative P2Y purinoceptor 10

1

8

High-throughput

0.489

High

164901

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

4

High-throughput

0.489

High

182466

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.489

High

275488

RTN2
Reticulon-2

1

1

High-throughput

0.489

High

380259

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

2

High-throughput

0.489

High

580731

PVR
Poliovirus receptor

1

5

High-throughput

0.489

High

665077

GLR
Glucagon receptor

1

3

High-throughput

0.489

High

665079

PTH2R
Parathyroid hormone 2 receptor

1

3

High-throughput

0.489

High

665083

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.489

High

665087

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

665091

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.489

High

665097

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

665102

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.489

High

665105

VASN
Vasorin

1

1

High-throughput

0.489

High

665109

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

1

High-throughput

0.489

High

665130

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.489

High

665133

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.489

High

665136

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.489

High

665142

TMPS5
Transmembrane protease serine 5

1

5

High-throughput

0.489

High

665120

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

High-throughput

0.481

High

665129

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

128783

MEN1
Menin

1

6

High-throughput

0.479

High

142838

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

164256

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

259453

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

380812

HBE
Hemoglobin subunit epsilon

1

3

Small-scale

0.479

High

473791

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

662371

GATA2
Endothelial transcription factor GATA-2

1

8

Small-scale

0.479

High

665082

FOXA1
Hepatocyte nuclear factor 3-alpha

1

18

High-throughput

0.479

High

665085

TFAP4
Transcription factor AP-4

1

3

Small-scale

0.479

High

665089

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

665096

CUL3
Cullin-3

1

9

High-throughput

0.479

High

665098

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

665119

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

665127

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

665131

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

20

Small-scale

0.479

High

665132

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

665145

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

20

High-throughput

0.479

High

665153

XPO7
Exportin-7

1

6

High-throughput

0.479

High

665154

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.479

High

665138

FACD2
Fanconi anemia group D2 protein

1

0

Small-scale

0.458

High

665149

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

665095

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.445

High

665128

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.439

High

380405

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.437

High

380615

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

1

High-throughput

0.437

High

665155

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.437

High

665104

Q5TF85
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

97124

E9PNY5
Fc gamma receptor IIIb

1

1

High-throughput

0.407

High

665103

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.407

High

665135

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

3

High-throughput

0.407

High

665076

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.328

High

665114

SPX3
Sugar phosphate exchanger 3

2

0

High-throughput

0.328

High

665146

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

665151

WNT16
Protein Wnt-16

2

0

High-throughput

0.328

High

665086

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.318

High

665137

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.318

High

665092

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.282

High

71195

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

183910

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.279

Low

230693

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

260740

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

407153

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.279

Low

549732

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

665080

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

665118

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

665126

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

665147

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

665156

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low

293214

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

665144

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

665099

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

0

High-throughput

0.232

Low

665115

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025