Protein: COT1
COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)

Gene: COT1, NR2F1
Organism: Homo sapiens
Interactions: 51
UniProt ID: P10589

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0004879 - nuclear receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

395375

ESR1
Estrogen receptor

2

20

Small-scale

0.847

High

522834

BC11B
B-cell lymphoma/leukemia 11B

2

18

Small-scale

0.636

High

522835

BC11A
BCL11 transcription factor A

2

16

Small-scale

0.622

High

522821

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.621

High

522840

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.621

High

522815

TF2B
Transcription initiation factor IIB

2

2

Small-scale

0.613

High

220469

RNF13
E3 ubiquitin-protein ligase RNF13

2

4

High-throughput

0.611

High

190700

MPPD1
Metallophosphoesterase domain-containing protein 1

3

5

High-throughput

0.609

High

464773

SP1
Transcription factor Sp1

2

20

Small-scale

0.602

High

522808

AHR
Aryl hydrocarbon receptor

2

20

Small-scale

0.602

High

522805

CD70
CD70 antigen

2

2

High-throughput

0.574

High

190040

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.561

High

522804

PO2F1
POU domain, class 2, transcription factor 1

1

20

Small-scale

0.561

High

522825

FOXP4
Forkhead box protein P4

1

20

Small-scale

0.561

High

522836

FOXP1
Forkhead box protein P1

1

20

Small-scale

0.561

High

182456

GP182
G-protein coupled receptor 182

2

9

High-throughput

0.549

High

220143

TNF14
Tumor necrosis factor ligand superfamily member 14

1

2

High-throughput

0.536

High

221911

FOXS1
Forkhead box protein S1

1

15

High-throughput

0.536

High

370526

FOS
Protein c-Fos

1

14

High-throughput

0.536

High

522810

FOXG1
Forkhead box protein G1

1

20

High-throughput

0.536

High

522811

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.536

High

522819

FOXL1
Forkhead box protein L1

1

14

High-throughput

0.536

High

522820

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.536

High

522829

GLMP
Glycosylated lysosomal membrane protein

1

1

High-throughput

0.536

High

522833

FOXC2
Forkhead box protein C2

1

20

High-throughput

0.536

High

478898

PO2F2
POU domain, class 2, transcription factor 2

1

20

Small-scale

0.501

High

507454

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

522809

CBX5
Chromobox protein homolog 5

1

19

Small-scale

0.501

High

522812

CSN2
COP9 signalosome complex subunit 2

1

2

Small-scale

0.501

High

522813

ISL1
Insulin gene enhancer protein ISL-1

1

8

Small-scale

0.501

High

522832

PHB2
Prohibitin-2

1

9

Small-scale

0.501

High

522807

BASI
Basigin

1

6

High-throughput

0.489

High

522822

MPPD2
Metallophosphoesterase MPPED2

1

5

High-throughput

0.489

High

522823

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.489

High

522839

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

522830

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

240572

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

522806

GRK5
G protein-coupled receptor kinase 5

1

14

High-throughput

0.479

High

522814

H4
Histone H4

1

3

High-throughput

0.479

High

522816

TFAP4
Transcription factor AP-4

1

3

Small-scale

0.479

High

522817

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.479

High

522818

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

522831

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

261757

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.464

High

522828

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

522824

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

522837

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

294653

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

522826

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

522827

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

522838

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025