HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	15707590, 22833562
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 665
+	Hs
		412296 FYN_HUMAN (1-536): 0: 598: 68.39		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		454842 FGR_HUMAN (1-535): 0: 583: 65.99		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		442869 HCK_HUMAN (1-531): 0: 569: 55.22		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		411817 LCK_HUMAN (75-534): 0: 552: 58.48		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		433938 LYN_HUMAN (1-531): 0: 532: 52.44		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		412426 FYN_HUMAN (1-536): 0: 598: 68.39		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		442898 HCK_HUMAN (1-531): 0: 569: 55.22		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		523022 SRC_HUMAN (1-536): 0: 651: 100.00		SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72
+	Hs
		522887 SRC_HUMAN (1-536): 0: 651: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		411986 FYN_HUMAN (1-536): 0: 598: 68.39		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Mm
		763403 FYN_MOUSE (1-536): 0: 597: 68.58		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Mm
		763393 FYN_MOUSE (1-536): 0: 597: 68.58		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		411981 FYN_HUMAN (1-536): 0: 598: 68.39		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Ce
		220205 SRC2_CAEEL (24-534): 0: 520: 50.10		SEM5_CAEEL (2-167): 1.56e-29: 118: 21.08
+	Hs
		433781 LYN_HUMAN (1-531): 0: 532: 52.44		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		411580 LCK_HUMAN (75-534): 0: 552: 58.48		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		433859 LYN_HUMAN (1-531): 0: 532: 52.44		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		209001 ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235483 ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		433807 LYN_HUMAN (1-531): 0: 532: 52.44		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31