Protein: DNMT1
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)

Gene: DNMT1
Organism: Homo sapiens
Interactions: 217
UniProt ID: P26358

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001674 - female germ cell nucleus
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003886 - DNA (cytosine-5-)-methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641270

UHRF1
E3 ubiquitin-protein ligase UHRF1

21

20

Small-scale

0.990

High

641255

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

14

5

Small-scale

0.985

High

641295

DNM3B
DNA

7

9

Small-scale

0.961

High

641190

H31
Histone H3.1

6

20

Small-scale

0.930

High

641305

DNM3A
DNA

3

9

Small-scale

0.857

High

641208

TIF1B
Transcription intermediary factor 1-beta

3

8

Small-scale

0.827

High

641269

UHRF2
E3 ubiquitin-protein ligase UHRF2

3

20

Small-scale

0.827

High

295939

MTA2
Metastasis-associated protein MTA2

3

3

Small-scale

0.817

High

641209

MTA1
Metastasis-associated protein MTA1

3

3

Small-scale

0.817

High

641185

H4
Histone H4

2

6

High-throughput

0.776

High

641229

H31T
Histone H3.1t

2

20

Small-scale

0.768

High

203628

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

12

Small-scale

0.754

High

226571

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

641165

CBX5
Chromobox protein homolog 5

2

20

Small-scale

0.754

High

641217

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

14

Small-scale

0.754

High

517066

PCNA
Proliferating cell nuclear antigen

10

4

Small-scale

0.753

High

641212

HDAC1
Histone deacetylase 1

10

13

Small-scale

0.750

High

641225

EZH2
Histone-lysine N-methyltransferase EZH2

6

20

Small-scale

0.736

High

474933

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

7

Small-scale

0.710

High

641252

HDAC2
Histone deacetylase 2

4

16

Small-scale

0.692

High

315971

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.691

High

641262

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

8

Small-scale

0.686

High

455107

PARP1
Poly [ADP-ribose] polymerase 1

4

10

Small-scale

0.680

High

414176

RB
Retinoblastoma-associated protein

3

3

Small-scale

0.678

High

641296

DAXX
Death domain-associated protein 6

4

2

Small-scale

0.676

High

641251

SETD7
Histone-lysine N-methyltransferase SETD7

2

1

Small-scale

0.674

High

641256

H2B1H
Histone H2B type 1-H

1

16

High-throughput

0.665

High

475362

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.647

High

641157

H2B1B
Histone H2B type 1-B

1

15

Small-scale

0.647

High

641192

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.647

High

641298

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

13

Small-scale

0.647

High

641283

DMAP1
DNA methyltransferase 1-associated protein 1

2

1

Small-scale

0.644

High

232007

KDM1A
Lysine-specific histone demethylase 1A

3

3

Small-scale

0.640

High

243961

BRD4
Bromodomain-containing protein 4

3

14

High-throughput

0.640

High

326448

SNAI1
Zinc finger protein SNAI1

3

3

Small-scale

0.640

High

345971

MYC
Myc proto-oncogene protein

3

14

High-throughput

0.640

High

386135

P53
Cellular tumor antigen p53

3

1

Small-scale

0.640

High

641267

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

18

Small-scale

0.640

High

267899

EED
Polycomb protein EED

2

18

Small-scale

0.635

High

641215

CUL4B
Cullin-4B

2

15

Small-scale

0.634

High

641196

RUNX1
Runt-related transcription factor 1

2

1

Small-scale

0.620

High

641226

DDB1
DNA damage-binding protein 1

2

6

Small-scale

0.619

High

641149

DNMT1
DNA

1

14

Small-scale

0.618

High

641169

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

641186

H2B1C
Histone H2B type 1-C/E/F/G/I

1

16

High-throughput

0.618

High

641193

H33
Histone H3.3

1

20

High-throughput

0.618

High

641207

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

641230

H2A2C
Histone H2A type 2-C

1

10

Small-scale

0.618

High

641293

CXXC1
CXXC-type zinc finger protein 1

1

5

Small-scale

0.618

High

641156

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.615

High

641159

CTNB1
Catenin beta-1

2

7

Small-scale

0.611

High

641187

1433Z
14-3-3 protein zeta/delta

2

10

High-throughput

0.611

High

641163

STAT3
Signal transducer and activator of transcription 3

2

2

Small-scale

0.601

High

641265

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

3

Small-scale

0.597

High

641167

NRIP1
Nuclear receptor-interacting protein 1

1

2

Small-scale

0.586

High

641264

DCAF5
DDB1- and CUL4-associated factor 5

1

6

Small-scale

0.586

High

641168

NR2C2
Nuclear receptor subfamily 2 group C member 2

2

13

Small-scale

0.584

High

641220

SUZ12
Polycomb protein SUZ12

2

6

Small-scale

0.584

High

641254

KAT5
Histone acetyltransferase KAT5

2

2

Small-scale

0.584

High

641183

1433E
14-3-3 protein epsilon

2

1

High-throughput

0.571

High

641294

MBD2
Methyl-CpG-binding domain protein 2

2

2

Small-scale

0.571

High

641219

PAF15
PCNA-associated factor

2

2

Small-scale

0.563

High

641174

MECP2
Methyl-CpG-binding protein 2

1

10

Small-scale

0.561

High

641288

HELLS
Lymphoid-specific helicase

1

20

Small-scale

0.561

High

154134

CHK1
Serine/threonine-protein kinase Chk1

2

0

Small-scale

0.559

High

641273

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

641202

MTG8
Protein CBFA2T1

1

2

Small-scale

0.552

High

641242

BRAP
BRCA1-associated protein

1

3

Small-scale

0.552

High

262152

TRIM3
Tripartite motif-containing protein 3

1

6

High-throughput

0.541

High

536735

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.541

High

641189

EF1A1
Elongation factor 1-alpha 1

1

7

High-throughput

0.541

High

641246

PHC2
Polyhomeotic-like protein 2

1

4

High-throughput

0.541

High

450728

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.537

High

319124

BRD1
Bromodomain-containing protein 1

1

9

Small-scale

0.536

High

641181

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

641228

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.536

High

87454

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

0

High-throughput

0.518

High

213712

ENSA
Alpha-endosulfine

1

0

High-throughput

0.518

High

641155

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.518

High

641266

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

641282

NGRN
Neugrin

1

0

High-throughput

0.518

High

641214

CUL4A
Cullin-4A

1

15

Small-scale

0.515

High

641218

LASP1
LIM and SH3 domain protein 1

1

1

Small-scale

0.512

High

641173

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.508

High

641188

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

641299

KS6A6
Ribosomal protein S6 kinase alpha-6

1

3

High-throughput

0.508

High

641172

RGS6
Regulator of G-protein signaling 6

1

3

Small-scale

0.501

High

641179

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

641253

KAT2B
Histone acetyltransferase KAT2B

1

16

Small-scale

0.501

High

68275

P20L1
PHD finger protein 20-like protein 1

1

0

Small-scale

0.493

High

641200

1433F
14-3-3 protein eta

1

10

High-throughput

0.489

High

265603

E2F6
Transcription factor E2F6

1

3

Small-scale

0.481

High

641175

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

Small-scale

0.480

High

161786

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

177200

HDAC3
Histone deacetylase 3

1

13

Small-scale

0.479

High

205065

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

229313

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

19

Small-scale

0.479

High

239306

CC14B
Dual specificity protein phosphatase CDC14B

1

7

High-throughput

0.479

High

261408

NCOR1
Nuclear receptor corepressor 1

1

7

High-throughput

0.479

High

312018

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

10

Small-scale

0.479

High

328498

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

373705

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

379033

MYCN
N-myc proto-oncogene protein

1

12

Small-scale

0.479

High

417161

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

434956

SP1
Transcription factor Sp1

1

13

Small-scale

0.479

High

456502

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

501709

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

503473

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

523533

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

525280

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

13

Small-scale

0.479

High

551988

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

569216

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

585885

WT1
Wilms tumor protein

1

17

Small-scale

0.479

High

622360

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.479

High

625122

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.479

High

631349

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

641150

PAX6
Paired box protein Pax-6

1

7

Small-scale

0.479

High

641152

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

641153

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

641158

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.479

High

641160

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

641162

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

641164

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

641166

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

641171

CEBPD
CCAAT/enhancer-binding protein delta

1

13

Small-scale

0.479

High

641176

FOXA1
Hepatocyte nuclear factor 3-alpha

1

4

High-throughput

0.479

High

641177

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

641180

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

641182

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

641184

RUXG
Small nuclear ribonucleoprotein G

1

1

Small-scale

0.479

High

641191

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.479

High

641194

VIGLN
Vigilin

1

6

High-throughput

0.479

High

641195

CDK5
Cyclin-dependent kinase 5

1

8

Small-scale

0.479

High

641197

RELB
Transcription factor RelB

1

4

Small-scale

0.479

High

641198

SP3
Transcription factor Sp3

1

11

Small-scale

0.479

High

641199

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

1

Small-scale

0.479

High

641201

UBE3A
Ubiquitin-protein ligase E3A

1

4

High-throughput

0.479

High

641203

RBBP4
Histone-binding protein RBBP4

1

8

Small-scale

0.479

High

641204

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

641205

TROP
Trophinin

1

2

High-throughput

0.479

High

641206

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

641210

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

641211

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

641213

CUL3
Cullin-3

1

15

High-throughput

0.479

High

641216

HIC1
Hypermethylated in cancer 1 protein

1

4

Small-scale

0.479

High

641221

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

641222

DPOD3
DNA polymerase delta subunit 3

1

1

Small-scale

0.479

High

641223

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

641227

RBBP7
Histone-binding protein RBBP7

1

8

Small-scale

0.479

High

641231

CDKL4
Cyclin-dependent kinase-like 4

1

8

High-throughput

0.479

High

641235

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

641238

BCOR
BCL-6 corepressor

1

13

Small-scale

0.479

High

641239

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

641240

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

641243

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

641247

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

641257

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

641259

MRTFA
Myocardin-related transcription factor A

1

4

Small-scale

0.479

High

641263

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

641275

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

641281

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

16

Small-scale

0.479

High

641284

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.479

High

641285

ANLN
Anillin

1

2

High-throughput

0.479

High

641286

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

641289

ZFP57
Zinc finger protein 57 homolog

1

2

Small-scale

0.479

High

641290

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

641291

DJC27
DnaJ homolog subfamily C member 27

1

3

High-throughput

0.479

High

641292

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

641297

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

641301

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

641303

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

257921

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

312897

SLU7
Pre-mRNA-splicing factor SLU7

1

0

Small-scale

0.458

High

538473

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

622921

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

Small-scale

0.458

High

641154

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.458

High

641178

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

641224

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

Small-scale

0.458

High

641245

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

641271

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

641272

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

641151

1433T
14-3-3 protein theta

1

10

High-throughput

0.457

High

401448

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

641244

STING
Stimulator of interferon genes protein

1

1

Small-scale

0.445

High

641274

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

48787

BLT3B
Bridge-like lipid transfer protein family member 3B

1

1

Small-scale

0.437

High

155784

UN13B
Protein unc-13 homolog B

1

1

High-throughput

0.437

High

384297

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

641233

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

641234

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

Small-scale

0.437

High

641236

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

641241

MYH14
Myosin-14

1

2

High-throughput

0.437

High

641248

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

641249

DJB14
DnaJ homolog subfamily B member 14

1

1

High-throughput

0.437

High

641258

ARL11
ADP-ribosylation factor-like protein 11

1

1

High-throughput

0.437

High

641260

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

High-throughput

0.437

High

641261

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.437

High

641268

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.437

High

641277

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

641278

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

641279

NSUN3
tRNA

1

2

High-throughput

0.437

High

641280

DJC18
DnaJ homolog subfamily C member 18

1

2

High-throughput

0.437

High

641300

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

641302

DJC16
DnaJ homolog subfamily C member 16

1

1

High-throughput

0.437

High

641304

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.437

High

641170

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.408

High

330858

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.407

High

641232

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.407

High

641287

PICK1
PRKCA-binding protein

1

0

High-throughput

0.304

High

63994

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

641250

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

451071

SPRC
SPARC

1

0

Small-scale

0.249

Low

641161

BASI
Basigin

1

0

High-throughput

0.249

Low

641237

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

641276

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.249

Low

581444

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024