HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: XRCC4 (Q13426)
DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]
Gene: XRCC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.698

The method score is based on:

Property Details
Experiments 26774286, 15520013, 26496610, 17124166
Identification Methods affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006303 - double-strand break repair via nonhomologous end joining
and 1 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 609
Hs

1 336
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024