Protein: NSUN2
RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)

Gene: NSUN2
Organism: Homo sapiens
Interactions: 214
UniProt ID: Q08J23

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

371868

MYC
Myc proto-oncogene protein

5

5

High-throughput

0.702

High

1050402

UBE3A
Ubiquitin-protein ligase E3A

3

2

High-throughput

0.667

High

167693

LIN7A
Protein lin-7 homolog A

2

1

High-throughput

0.628

High

622801

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

2

4

High-throughput

0.628

High

1066139

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

2

2

High-throughput

0.628

High

1066193

LIN7C
Protein lin-7 homolog C

2

1

High-throughput

0.628

High

1066112

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

5

High-throughput

0.618

High

446948

NPM
Nucleophosmin

2

3

Small-scale

0.611

High

1066118

CUL3
Cullin-3

2

4

High-throughput

0.611

High

1066127

IF16
Gamma-interferon-inducible protein 16

2

3

High-throughput

0.611

High

1066129

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.611

High

1066209

NGN3
Neurogenin-3

2

1

Small-scale

0.611

High

1066166

CNDP2
Cytosolic non-specific dipeptidase

2

0

High-throughput

0.602

High

1066197

PALS2
Protein PALS2

2

0

High-throughput

0.602

High

563683

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

1066119

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.585

High

241506

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

259854

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.584

High

411815

NTRK1
High affinity nerve growth factor receptor

2

7

High-throughput

0.584

High

830626

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

1066191

ANLN
Anillin

2

3

High-throughput

0.584

High

400718

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

1066142

LCA5
Lebercilin

2

2

High-throughput

0.571

High

619763

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

274547

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.536

High

342166

BRD1
Bromodomain-containing protein 1

1

3

Small-scale

0.536

High

431105

LA
Lupus La protein

1

2

High-throughput

0.536

High

572817

NCF1
Neutrophil cytosol factor 1

1

1

High-throughput

0.536

High

693711

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

859249

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.536

High

969816

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

985630

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

996920

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.536

High

1038430

TIE2
Angiopoietin-1 receptor

1

6

High-throughput

0.536

High

1066117

CUL1
Cullin-1

1

4

High-throughput

0.536

High

1066141

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1066152

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

1066157

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

1066158

CUL5
Cullin-5

1

4

High-throughput

0.536

High

1066165

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

873947

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

187069

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

361231

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

407616

S100B
Protein S100-B

1

0

High-throughput

0.513

High

529701

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

732560

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

884075

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

973410

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

1066125

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1066167

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.513

High

1066210

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

1066211

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

964243

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

1066162

AURKB
Aurora kinase B

1

1

Small-scale

0.501

High

339729

KLF8
Krueppel-like factor 8

1

8

High-throughput

0.500

High

1066175

KLF16
Krueppel-like factor 16

1

7

High-throughput

0.500

High

1066202

KLF15
Krueppel-like factor 15

1

6

High-throughput

0.500

High

1066201

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

711879

LTK
Leukocyte tyrosine kinase receptor

1

11

High-throughput

0.489

High

1041982

LMNB2
Lamin-B2

1

3

High-throughput

0.489

High

1051998

CALD1
Caldesmon

1

4

High-throughput

0.489

High

1066174

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

131991

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

138086

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

194158

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

222977

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

247855

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

293620

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315509

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

319709

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

330902

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

335110

ARI2
E3 ubiquitin-protein ligase ARIH2

1

6

High-throughput

0.479

High

345716

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

363186

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

406107

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

465501

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.479

High

470996

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

472680

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

519985

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

537047

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

541452

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.479

High

558074

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

588547

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606687

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

620323

NUCL
Nucleolin

1

1

Small-scale

0.479

High

643804

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

695302

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

699721

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

710818

EPHB2
Ephrin type-B receptor 2

1

4

High-throughput

0.479

High

720203

UFO
Tyrosine-protein kinase receptor UFO

1

10

High-throughput

0.479

High

766490

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

768042

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

777675

VGFR3
Vascular endothelial growth factor receptor 3

1

6

High-throughput

0.479

High

778057

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.479

High

879011

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

891495

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

897767

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

907399

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

928686

PMS2
Mismatch repair endonuclease PMS2

1

2

High-throughput

0.479

High

937727

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

940934

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

964890

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

970403

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

976229

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

978893

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

984086

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

986012

RL8
Large ribosomal subunit protein uL2

1

3

High-throughput

0.479

High

1004489

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.479

High

1034149

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

13

High-throughput

0.479

High

1045220

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1066113

MERTK
Tyrosine-protein kinase Mer

1

10

High-throughput

0.479

High

1066115

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

1066116

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

1066121

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

1066122

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

1066123

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1066124

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1066126

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1066130

ZN746
Zinc finger protein 746

1

8

High-throughput

0.479

High

1066135

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1066138

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1066140

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1066145

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

1066147

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1066154

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.479

High

1066155

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1066156

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

1066159

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

1066160

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1066163

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1066168

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1066170

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1066172

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

1066176

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1066178

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.479

High

1066181

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1066183

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

1066184

SENP3
Sentrin-specific protease 3

1

2

Small-scale

0.479

High

1066185

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1066187

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1066188

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

1066189

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.479

High

1066190

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

1066192

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1066194

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1066198

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

1066200

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1066204

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1066205

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.479

High

1066206

CE164
Centrosomal protein of 164 kDa

1

2

High-throughput

0.479

High

1066208

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

134702

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

218107

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

482456

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

565360

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

657546

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

867073

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1066114

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1066131

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1066136

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1066149

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1066150

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1066151

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1066153

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.458

High

1066173

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1066180

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1066182

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1066195

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1066196

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

429784

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

626198

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

994493

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.445

High

1066120

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

1066128

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

157287

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

477232

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

9

High-throughput

0.437

High

609991

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

640154

EPHA1
Ephrin type-A receptor 1

1

4

High-throughput

0.437

High

650141

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.437

High

787007

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

1017694

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.437

High

1049143

RON
Macrophage-stimulating protein receptor

1

9

High-throughput

0.437

High

1066132

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

1066144

LMTK2
Serine/threonine-protein kinase LMTK2

1

8

High-throughput

0.437

High

1066146

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1066169

LMTK3
Serine/threonine-protein kinase LMTK3

1

10

High-throughput

0.437

High

1066203

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

1066143

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1066161

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

886796

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

1017592

PR20E
Proline-rich protein 20E

1

1

High-throughput

0.407

High

164322

NRP1
Neuropilin-1

3

0

High-throughput

0.347

High

1064978

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

906969

CCR4
C-C chemokine receptor type 4

1

0

High-throughput

0.282

High

1066177

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

353287

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

179881

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

239823

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

377554

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

378071

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

861136

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

888451

TSP3
Thrombospondin-3

1

0

High-throughput

0.249

Low

1066133

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1066171

ZFY21
Zinc finger FYVE domain-containing protein 21

1

0

Small-scale

0.249

Low

1066207

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

133495

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

1066134

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1066137

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

1066148

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1066164

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

1066179

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low

1066186

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low

1066199

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025