HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	15782130, 22990118
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~Ku, BRCT~Ku_C
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 777
+	Hs
		525035 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		166878 XRCC6_HUMAN (1-609): 0: 666: 100.00		ANR28_HUMAN (221-515): 1.02e-47: 185: 17.16
+	Hs
		310032 XRCC6_HUMAN (1-609): 0: 666: 100.00		TNKS1_HUMAN (364-552): 9.86e-28: 122: 23.98
+	Hs
		523935 XRCC6_HUMAN (1-609): 0: 666: 100.00		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		525018 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90