Protein: FBXW2
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)

Gene: FBXW2
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9UKT8

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0036211 - protein modification process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992390

SKP1
S-phase kinase-associated protein 1

15

20

Small-scale

0.983

High

1112787

CUL1
Cullin-1

11

20

Small-scale

0.973

High

1461219

FBW1A
F-box/WD repeat-containing protein 1A

3

19

Small-scale

0.879

High

1388934

FBX17
F-box only protein 17

3

2

High-throughput

0.861

High

1461220

FBX7
F-box only protein 7

3

2

High-throughput

0.861

High

1380245

FBXW7
F-box/WD repeat-containing protein 7

2

17

High-throughput

0.811

High

1101928

SKP2
S-phase kinase-associated protein 2

2

5

Small-scale

0.806

High

993015

RACK1
Small ribosomal subunit protein RACK1

1

18

Small-scale

0.739

High

996039

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

11

High-throughput

0.691

High

984023

RBX1
E3 ubiquitin-protein ligase RBX1

3

12

Small-scale

0.656

High

883364

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

17

Small-scale

0.647

High

982361

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

10

Small-scale

0.647

High

1461221

ARI1
E3 ubiquitin-protein ligase ARIH1

2

13

High-throughput

0.628

High

765106

CTNB1
Catenin beta-1

2

20

Small-scale

0.624

High

1328148

TTC9C
Tetratricopeptide repeat protein 9C

1

11

High-throughput

0.618

High

1420547

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.618

High

1325534

FBXW8
F-box/WD repeat-containing protein 8

1

16

Small-scale

0.618

High

1448315

FBX6
F-box only protein 6

1

2

High-throughput

0.618

High

1208288

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

3

2

High-throughput

0.609

High

462033

HS90A
Heat shock protein HSP 90-alpha

2

17

High-throughput

0.584

High

1158597

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.584

High

1445868

GCM1
Chorion-specific transcription factor GCMa

2

3

Small-scale

0.573

High

468905

HS90B
Heat shock protein HSP 90-beta

2

18

High-throughput

0.571

High

772214

MSX2
Homeobox protein MSX-2

1

5

Small-scale

0.561

High

1045894

TF65
Transcription factor p65

1

13

Small-scale

0.561

High

1241979

FBX42
F-box only protein 42

1

9

High-throughput

0.553

High

1461218

NUDC
Nuclear migration protein nudC

1

16

High-throughput

0.536

High

1419264

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.518

High

668067

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.481

High

214062

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

4

Small-scale

0.479

High

731693

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.479

High

1008539

BTG2
Protein BTG2

1

7

Small-scale

0.479

High

1067824

EP300
Histone acetyltransferase p300

1

11

Small-scale

0.479

High

1095322

REST
RE1-silencing transcription factor

1

4

Small-scale

0.479

High

1358138

NUDC2
NudC domain-containing protein 2

1

16

High-throughput

0.479

High

1370870

FUBP2
Far upstream element-binding protein 2

1

19

Small-scale

0.479

High

1437974

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

1460457

FKBPL
FK506-binding protein-like

1

14

High-throughput

0.479

High

76587

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.437

High

974913

BTG1
Protein BTG1

1

7

Small-scale

0.437

High

1198802

Q53FC7
Heat shock 70 kDa protein 6

1

10

High-throughput

0.437

High

1245583

Q6PK50
HSP90AB1 protein

1

18

High-throughput

0.437

High

1409574

Q9BPW0
Serine/threonine-protein phosphatase

1

9

High-throughput

0.437

High

1211388

CLVS2
Clavesin-2

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025