HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18936166, 22990118
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~Ku, BRCT~Ku_C
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 777
+	Hs
		523964 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		525018 XRCC5_HUMAN (1-732): 0: 755: 100.00		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		166878 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ANR28_HUMAN (221-515): 1.02e-47: 185: 17.16
+	Hs
		310032 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TNKS1_HUMAN (364-552): 9.86e-28: 122: 23.98
+	Hs
		523935 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90