HitPredict

Interactor 1: TDGF1 (P13385)
Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1)
Gene: CRIPTO

Interactor 2: NODAL (Q96S42)
Nodal homolog
Gene: NODAL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28126904
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0008083 - growth factor activity GO:0038092 - nodal signaling pathway
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 188 Hs			1 347
+	Hs
		526872 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMP7_HUMAN (36-346): 1.79e-94: 289: 23.78
+	Hs
		526873 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMP6_HUMAN (15-346): 3.64e-91: 283: 21.28
+	Hs
		520088 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMP4_HUMAN (28-346): 7.4e-92: 282: 24.80
+	Hs
		526921 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF3_HUMAN (28-346): 8.51e-71: 226: 21.59
+	Hs
		451816 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		INHBB_HUMAN (53-346): 5.51e-62: 205: 21.33
+	Mm
		792909 CFC1_MOUSE (82-150): 1.88e-39: 135: 50.73		NODAL_MOUSE (1-347): 6.06e-125: 364: 78.81
+	Hs
		233921 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF9_HUMAN (183-346): 2.28e-42: 154: 23.95
+	Mm
		851053 TDGF1_MOUSE (6-182): 2.3e-99: 286: 67.23		LFTY1_MOUSE (55-346): 4.28e-58: 193: 14.47
+	Hs
		312844 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF11_HUMAN (199-346): 1.04e-35: 135: 27.92
+	Hs
		474690 CFC1_HUMAN (52-150): 3.46e-39: 135: 41.41		BMP4_HUMAN (28-346): 7.4e-92: 282: 24.80
+	Hs
		474736 CFC1_HUMAN (52-150): 3.46e-39: 135: 41.41		BMP8A_HUMAN (39-346): 6.41e-81: 253: 26.10
+	Hs
		474769 CFC1_HUMAN (52-150): 3.46e-39: 135: 41.41		GDF15_HUMAN (188-347): 4.86e-30: 118: 23.93