HitPredict

Interactor 1: LAMP2 (P13473)
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Gene: LAMP2

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	28514442, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 410 Hs			1 184
+	Hs
		527382 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27
+	Hs
		527662 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB2B_HUMAN (1-170): 1.32e-76: 229: 30.41
+	Hs
		527381 LAMP2_HUMAN (1-410): 0: 557: 100.00		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		527778 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41
+	Hs
		527374 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Hs
		527357 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB13_HUMAN (1-180): 8.32e-73: 219: 28.42
+	Hs
		527383 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAP1A_HUMAN (5-163): 2.2e-36: 126: 40.85
+	Hs
		506956 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27
+	Hs
		506955 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		507225 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41
+	Hs
		506355 LAMP2_HUMAN (1-410): 0: 557: 100.00		RALA_HUMAN (8-171): 2.87e-31: 114: 35.54
+	Hs
		506950 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Hs
		486009 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAP2A_HUMAN (19-183): 6.71e-30: 109: 38.24
+	Hs
		506932 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		RAB13_HUMAN (1-180): 8.32e-73: 219: 28.42
+	Hs
		918969 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27
+	Hs
		914467 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		1328159 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41
+	Hs
		895323 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Hs
		845893 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RAB13_HUMAN (1-180): 8.32e-73: 219: 28.42
+	Hs
		486058 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RAP2A_HUMAN (19-183): 6.71e-30: 109: 38.24