HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: PDIA6 (Q15084)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	26618866, 31324722, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 440
+	Hs
		529425 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TXND5_HUMAN (177-431): 3.21e-41: 153: 20.37
+	Hs
		528451 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28
+	Hs
		529571 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TMX3_HUMAN (3-127): 8.56e-18: 87: 35.94
+	Hs
		423122 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59
+	Hs
		528620 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA3_HUMAN (13-386): 9.31e-10: 62.6: 11.02