HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: GNAS1 (Q5JWF2)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	29924966
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0016324 - apical plasma membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1037
+	Hs
		528938 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAS2_HUMAN (649-1037): 3.29e-180: 531: 93.83
+	Hs
		391317 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAI2_HUMAN (651-1037): 7.31e-168: 498: 38.76
+	Hs
		444657 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAI3_HUMAN (651-1037): 1.17e-167: 497: 38.50
+	Hs
		528614 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNA11_HUMAN (650-1037): 8.8e-159: 474: 37.63
+	Hs
		528513 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAZ_HUMAN (651-1036): 1.41e-150: 453: 36.60