HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DNJC1 (Q96KC8)
DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)
Gene: DNAJC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35156780
Identification Methods	protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0051087 - protein-folding chaperone binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 554
+	Hs
		279273 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB5_HUMAN (62-305): 1.17e-47: 171: 14.89
+	Hs
		529804 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB12_HUMAN (44-287): 5.13e-46: 167: 18.11
+	Hs
		529452 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB14_HUMAN (46-348): 3.04e-43: 160: 18.03
+	Hs
		529547 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJA3_HUMAN (13-217): 1.05e-41: 158: 21.43
+	Hs
		528576 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB1_HUMAN (62-316): 5.43e-42: 155: 14.55
+	Hs
		529935 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJC16_HUMAN (55-230): 1.64e-39: 155: 23.46
+	Hs
		529849 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB11_HUMAN (62-138): 7.23e-37: 141: 50.00
+	Hs
		529482 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB3_HUMAN (64-136): 6.42e-35: 130: 44.00
+	Hs
		257902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB6_HUMAN (64-126): 1.3e-11: 67.8: 52.31
+	Dm
		1182053 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		Q9VS57_DROME (10-538): 4.02e-47: 177: 13.08
+	Sc
		633231 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		MAS5_YEAST (58-133): 1.81e-34: 136: 44.74