Protein: DYN1
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)

Gene: DYN1, DNM1
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q05193

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987565

GRB2
Growth factor receptor-bound protein 2

15

20

Small-scale

0.985

High

1050673

DYN1
Dynamin-1

8

16

Small-scale

0.970

High

1050728

SNX9
Sorting nexin-9

7

15

Small-scale

0.968

High

1050725

DYN3
Dynamin-3

4

17

High-throughput

0.903

High

896732

DYN2
Dynamin-2

4

17

High-throughput

0.900

High

1050678

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

3

10

Small-scale

0.854

High

1050684

ITSN1
Intersectin-1

2

14

Small-scale

0.825

High

593970

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.819

High

1050702

SNX33
Sorting nexin-33

2

14

Small-scale

0.802

High

557244

SRC
Proto-oncogene tyrosine-protein kinase Src

2

11

Small-scale

0.789

High

1050710

SH3G1
Endophilin-A2

2

20

Small-scale

0.778

High

883038

AMPH
Amphiphysin

10

19

Small-scale

0.757

High

1050693

DNMBP
Dynamin-binding protein

1

20

Small-scale

0.724

High

1050718

PLK2
Serine/threonine-protein kinase PLK2

1

5

Small-scale

0.724

High

1050709

FNBP1
Formin-binding protein 1

1

20

Small-scale

0.690

High

1050689

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

Small-scale

0.683

High

262219

SCN2B
Sodium channel regulatory subunit beta-2

3

3

High-throughput

0.667

High

1050685

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.667

High

1050697

LYPD6
Ly6/PLAUR domain-containing protein 6

3

2

High-throughput

0.667

High

1050717

KTU
Protein kintoun

3

2

High-throughput

0.667

High

1050722

NUFP1
FMR1-interacting protein NUFIP1

3

2

High-throughput

0.667

High

1025450

CDK5
Cyclin-dependent kinase 5

1

3

Small-scale

0.647

High

1038569

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

6

Small-scale

0.647

High

529678

TAU
Microtubule-associated protein tau

2

11

High-throughput

0.628

High

1050701

TBC15
TBC1 domain family member 15

2

3

High-throughput

0.628

High

1050716

S39A9
Zinc transporter ZIP9

2

1

High-throughput

0.628

High

1050711

SH3G2
Endophilin-A1

2

20

Small-scale

0.619

High

222060

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.618

High

362253

ABL1
Tyrosine-protein kinase ABL1

1

11

High-throughput

0.618

High

411781

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.618

High

1050674

FAK1
Focal adhesion kinase 1

1

17

Small-scale

0.618

High

1050675

MYO1E
Unconventional myosin-Ie

1

3

Small-scale

0.618

High

1050679

FAK2
Protein-tyrosine kinase 2-beta

1

17

Small-scale

0.618

High

1050688

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.618

High

1050713

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.618

High

1050720

SH3B4
SH3 domain-binding protein 4

1

1

Small-scale

0.618

High

1050712

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

20

Small-scale

0.611

High

124315

HAX1
HCLS1-associated protein X-1

3

1

High-throughput

0.609

High

943755

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

16

Small-scale

0.601

High

1050681

SMC1A
Structural maintenance of chromosomes protein 1A

2

3

High-throughput

0.601

High

1050715

TMM9B
Transmembrane protein 9B

2

6

High-throughput

0.574

High

1050708

SPTCS
Spatacsin

2

0

Small-scale

0.566

High

421967

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.554

High

1050707

AURKB
Aurora kinase B

1

2

High-throughput

0.553

High

991301

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.541

High

340112

PCNT
Pericentrin

1

4

High-throughput

0.541

High

876672

HSP13
Heat shock 70 kDa protein 13

1

9

High-throughput

0.541

High

230954

TYOBP
TYRO protein tyrosine kinase-binding protein

1

2

High-throughput

0.536

High

239041

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.536

High

388180

GLPA
Glycophorin-A

1

5

High-throughput

0.536

High

391229

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

749193

CD70
CD70 antigen

1

1

High-throughput

0.536

High

774307

BASI
Basigin

1

2

High-throughput

0.536

High

906874

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.536

High

914247

EFNA4
Ephrin-A4

1

6

High-throughput

0.536

High

1050704

AQP3
Aquaporin-3

1

10

High-throughput

0.536

High

138481

BIN1
Myc box-dependent-interacting protein 1

1

20

Small-scale

0.527

High

351481

FTCD
Formimidoyltransferase-cyclodeaminase

1

0

High-throughput

0.518

High

1050721

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

1050726

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.518

High

1050698

NOSTN
Nostrin

1

20

Small-scale

0.515

High

882459

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

1050683

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1050714

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

1050723

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

20

Small-scale

0.501

High

1050724

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

20

Small-scale

0.501

High

1050703

ASB13
Ankyrin repeat and SOCS box protein 13

1

2

High-throughput

0.494

High

70890

ZBBX
Zinc finger B-box domain-containing protein 1

1

2

High-throughput

0.489

High

230699

NKG2F
NKG2-F type II integral membrane protein

1

2

High-throughput

0.489

High

1050690

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.489

High

1050691

ANR22
Ankyrin repeat domain-containing protein 22

1

4

High-throughput

0.489

High

1050692

ASCL4
Achaete-scute homolog 4

1

1

High-throughput

0.489

High

1050696

AMGO1
Amphoterin-induced protein 1

1

3

High-throughput

0.489

High

1050719

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.489

High

791319

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

993514

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.481

High

1050680

EPN4
Clathrin interactor 1

1

0

Small-scale

0.480

High

474628

VIME
Vimentin

1

1

High-throughput

0.479

High

487222

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

572438

DRD2
D(2) dopamine receptor

1

3

Small-scale

0.479

High

584748

NDKA
Nucleoside diphosphate kinase A

1

5

Small-scale

0.479

High

612995

EGR1
Early growth response protein 1

1

1

Small-scale

0.479

High

713086

NOS3
Nitric oxide synthase 3

1

1

Small-scale

0.479

High

861131

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

904630

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1050677

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1050694

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1050705

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.479

High

843501

HD
Huntingtin

1

4

High-throughput

0.457

High

1050686

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.457

High

934506

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

1050682

LASP1
LIM and SH3 domain protein 1

1

20

Small-scale

0.445

High

297581

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

Small-scale

0.439

High

105798

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

768013

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1050729

CABIN
Calcineurin-binding protein cabin-1

1

1

Small-scale

0.437

High

1050687

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1050676

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1050727

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.282

High

1050700

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1050706

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.279

Low

1050695

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

1050699

U2D2L
Putative ubiquitin-conjugating enzyme E2 D2-like protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025